{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tomas-Ojer P"],"funding":["European Research Council"],"pagination":["790884"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8852676"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["Antigen-induced T-cell exhaustion and T-cell senescence are peripheral regulatory mechanisms that control effector T-cell responses. Markers of exhaustion and senescence on T Cells indicate the previous activation by repetitive stimulation with specific antigens. Malignant tumors are accompanied by enhanced T-cell exhaustion and T-cell senescence resulting in immune evasion, while these control mechanisms might be diminished in autoimmune diseases including multiple sclerosis (MS). To better understand the involvement of antigen-induced T-cell senescence in controlling CD4+ T-cell-mediated autoimmune responses in MS, we have analyzed the re-expression of CD45RA and the downregulation of CD28 and CD27 molecules as markers of antigen-induced T-cell senescence in fresh cerebrospinal fluid (CS"],"journal":["Frontiers in neurology"],"pubmed_title":["Characterization of Antigen-Induced CD4+ T-Cell Senescence in Multiple Sclerosis."],"pmcid":["PMC8852676"],"funding_grant_id":["340733"],"pubmed_authors":["Docampo MJ","Cruciani C","Sospedra M","Puthenparampil M","Tomas-Ojer P","Martin R"],"additional_accession":[]},"is_claimable":false,"name":"Characterization of Antigen-Induced CD4+ T-Cell Senescence in Multiple Sclerosis.","description":"Antigen-induced T-cell exhaustion and T-cell senescence are peripheral regulatory mechanisms that control effector T-cell responses. Markers of exhaustion and senescence on T Cells indicate the previous activation by repetitive stimulation with specific antigens. Malignant tumors are accompanied by enhanced T-cell exhaustion and T-cell senescence resulting in immune evasion, while these control mechanisms might be diminished in autoimmune diseases including multiple sclerosis (MS). To better understand the involvement of antigen-induced T-cell senescence in controlling CD4+ T-cell-mediated autoimmune responses in MS, we have analyzed the re-expression of CD45RA and the downregulation of CD28 and CD27 molecules as markers of antigen-induced T-cell senescence in fresh cerebrospinal fluid (CS","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T20:50:23.652Z","creation":"2025-04-04T20:50:23.652Z"},"accession":"S-EPMC8852676","cross_references":{"pubmed":["35185762"],"doi":["10.3389/fneur.2022.790884"]}}