{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Stanhewicz AE"],"funding":["NCATS NIH HHS","NIA NIH HHS","NHLBI NIH HHS"],"pagination":["81-86"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8858855"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27"],"pubmed_abstract":["Women who have had preeclampsia demonstrate microvascular endothelial-dysfunction, mediated in part by reduced nitric oxide (NO)-dependent dilation. Preeclamptic pregnancies are associated with elevated inflammation, and inhibition of inflammation attenuates endothelial damage in animal models of preeclampsia. However, it is unclear if inhibition of vascular inflammation improves endothelial function in women after a preeclamptic pregnancy. Using the cutaneous microcirculation as a model, we hypothesized that acute systemic inhibition of vascular inflammation (oral salsalate; 1500 mg/twice daily, 4 days) would improve endothelium- and NO-dependent vasodilation in women with a history of preeclampsia (PE) but not in women with a history of uncomplicated pregnancy (HC). Twelve HC (30 ± 1yrs,"],"journal":["Pregnancy hypertension"],"pubmed_title":["Acute systemic inhibition of inflammation augments endothelium-dependent dilation in women with a history of preeclamptic pregnancy."],"pmcid":["PMC8858855"],"funding_grant_id":["F32 HL129677","T32 AG049676","K99 HL138133","UL1 TR002537","R01 HL093238","R00 HL138133"],"pubmed_authors":["Alexander LM","Stanhewicz AE","Dillon GA","Serviente C"],"additional_accession":[]},"is_claimable":false,"name":"Acute systemic inhibition of inflammation augments endothelium-dependent dilation in women with a history of preeclamptic pregnancy.","description":"Women who have had preeclampsia demonstrate microvascular endothelial-dysfunction, mediated in part by reduced nitric oxide (NO)-dependent dilation. Preeclamptic pregnancies are associated with elevated inflammation, and inhibition of inflammation attenuates endothelial damage in animal models of preeclampsia. However, it is unclear if inhibition of vascular inflammation improves endothelial function in women after a preeclamptic pregnancy. Using the cutaneous microcirculation as a model, we hypothesized that acute systemic inhibition of vascular inflammation (oral salsalate; 1500 mg/twice daily, 4 days) would improve endothelium- and NO-dependent vasodilation in women with a history of preeclampsia (PE) but not in women with a history of uncomplicated pregnancy (HC). Twelve HC (30 ± 1yrs,","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-19T22:05:06.052Z","creation":"2024-11-11T18:59:24.138Z"},"accession":"S-EPMC8858855","cross_references":{"pubmed":["34973597"],"doi":["10.1016/j.preghy.2021.12.010"]}}