{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Noe A"],"funding":["Medical Research Council","National Institute for Health Research (NIHR)"],"pagination":["795463"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8859435"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["Protection from liver-stage malaria requires high numbers of CD8+ T cells to find and kill <i>Plasmodium</i>-infected cells. A new malaria vaccine strategy, prime-target vaccination, involves sequential viral-vectored vaccination by intramuscular and intravenous routes to target cellular immunity to the liver. Liver tissue-resident memory (TRM) CD8+ T cells have been shown to be necessary and sufficient for protection against rodent malaria by this vaccine regimen. Ultimately, to most faithfully assess immunotherapeutic responses by these local, specialised, hepatic T cells, periodic liver sampling is necessary, however this is not feasible at large scales in human trials. Here, as part of a phase I/II <i>P. falciparum</i> challenge study of prime-target vaccination, we performed deep immu"],"journal":["Frontiers in immunology"],"pubmed_title":["Deep Immune Phenotyping and Single-Cell Transcriptomics Allow Identification of Circulating TRM-Like Cells Which Correlate With Liver-Stage Immunity and Vaccine-Induced Protection From Malaria."],"pmcid":["PMC8859435"],"funding_grant_id":["MR/R015236/1"],"pubmed_authors":["Sheridan J","Datoo MS","Ewer KJ","Spencer AJ","Prasad N","Ramos Lopez F","Morter R","Voukantsis D","Hill AVS","Makinson RA","Jenkin D","Noe A","Flaxman A","Husainy MA","Bellamy D"],"additional_accession":[]},"is_claimable":false,"name":"Deep Immune Phenotyping and Single-Cell Transcriptomics Allow Identification of Circulating TRM-Like Cells Which Correlate With Liver-Stage Immunity and Vaccine-Induced Protection From Malaria.","description":"Protection from liver-stage malaria requires high numbers of CD8+ T cells to find and kill <i>Plasmodium</i>-infected cells. A new malaria vaccine strategy, prime-target vaccination, involves sequential viral-vectored vaccination by intramuscular and intravenous routes to target cellular immunity to the liver. Liver tissue-resident memory (TRM) CD8+ T cells have been shown to be necessary and sufficient for protection against rodent malaria by this vaccine regimen. Ultimately, to most faithfully assess immunotherapeutic responses by these local, specialised, hepatic T cells, periodic liver sampling is necessary, however this is not feasible at large scales in human trials. Here, as part of a phase I/II <i>P. falciparum</i> challenge study of prime-target vaccination, we performed deep immu","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-31T19:56:33.011Z","creation":"2025-04-19T22:37:53.549Z"},"accession":"S-EPMC8859435","cross_references":{"pubmed":["35197971"],"doi":["10.3389/fimmu.2022.795463"]}}