biostudies-literatureMiller RLNational Institute of Neurological Disorders and StrokeNINDS NIH HHSMichael J. Fox Foundation for Parkinson&apos;s Research106-121https://www.ebi.ac.uk/biostudies/studies/S-EPMC8862415biostudies-literatureUnknown9(2)<h4>Objective</h4>Parkinson disease (PD) is defined by the accumulation of misfolded α-synuclein (α-syn) in Lewy bodies and Lewy neurites. It affects multiple cortical and subcortical neuronal populations. The majority of people with PD develop dementia, which is associated with Lewy bodies in neocortex and referred to as Lewy body dementia (LBD). Other neuropathologic changes, including amyloid β (Aβ) and tau accumulation, occur in some LBD cases. We sought to quantify α-syn, Aβ, and tau accumulation in neocortical, limbic, and basal ganglia regions.<h4>Methods</h4>We isolated insoluble protein from fresh frozen postmortem brain tissue samples for eight brains regions from 15 LBD, seven Alzheimer disease (AD), and six control cases. We measured insoluble α-syn, Aβ, and tau with recently dAnnals of clinical and translational neurologyQuantifying regional α -synuclein, amyloid β, and tau accumulation in lewy body dementia.PMC8862415NS075321R01 NS097799R01 NS097437NS097799NS097437NS110436Liu JO'Shea JYCairns NJCampbell MCFranklin EEMiller RLCirrito JRPerlmutter JSBuddhala CKotzbauer PTDhavale DDLoftin SKAndruska KMPerrin RJfalseQuantifying regional α -synuclein, amyloid β, and tau accumulation in lewy body dementia.<h4>Objective</h4>Parkinson disease (PD) is defined by the accumulation of misfolded α-synuclein (α-syn) in Lewy bodies and Lewy neurites. It affects multiple cortical and subcortical neuronal populations. The majority of people with PD develop dementia, which is associated with Lewy bodies in neocortex and referred to as Lewy body dementia (LBD). Other neuropathologic changes, including amyloid β (Aβ) and tau accumulation, occur in some LBD cases. We sought to quantify α-syn, Aβ, and tau accumulation in neocortical, limbic, and basal ganglia regions.<h4>Methods</h4>We isolated insoluble protein from fresh frozen postmortem brain tissue samples for eight brains regions from 15 LBD, seven Alzheimer disease (AD), and six control cases. We measured insoluble α-syn, Aβ, and tau with recently d2022-01-01T00:00:00Z2022 Feb2025-04-18T16:35:43.959Z2025-04-07T03:56:17.645ZS-EPMC88624153506036010.1002/acn3.51482