{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Luo Q"],"funding":["Natural Science Foundation of Jiangxi Province","Jiangxi Provincial Natural Science Foundation of China","Key Research and Development Program of Jiangxi Province","the Science and Technology Plan Project of the Education Department of Jiangxi Province","the National Natural Science Foundation of China","the Science and Technology Project of Health and Family Planning Commission of Jiangxi Province of China","the Foundation for Distinguished Young Scientists of Jiangxi Province of china"],"pagination":["47-56"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8863699"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["It is well established that natural killer (NK) cells are dysregulated in systemic lupus erythematosus (SLE) patients. However, the functions of NK cells and the mechanisms regulated by them in SLE remain incompletely understood. Patients with SLE were recruited from The First Affiliated Hospital of Nanchang University, and their clinical characteristics and treatments were recorded. The expression levels of T cell immunoglobulin mucin-3 (TIM-3) and programmed cell death protein 1 (PD-1) on NK cells were examined using flow cytometry. The correlations between the increase in TIM-3<sup>+</sup>PD-1<sup>+</sup> NK cells in the SLE patients and clinical traits, including inflammatory markers, auto-antibodies, disease activity and severity of SLE, were examined. The TIM-3<sup>+</sup>NK cells, P"],"journal":["Clinical and experimental medicine"],"pubmed_title":["Increased TIM-3<sup>+</sup>PD-1<sup>+</sup> NK cells are associated with the disease activity and severity of systemic lupus erythematosus."],"pmcid":["PMC8863699"],"funding_grant_id":["20171BAB205113","81660277","81760297","170008","20151BAB215031","20181BBG70013","20165094","81360459","20171BCB23087","20202BABL206044"],"pubmed_authors":["Fu B","Li X","Luo Q","Li J","Huang Z","Huang Q","Kong Y"],"additional_accession":[]},"is_claimable":false,"name":"Increased TIM-3<sup>+</sup>PD-1<sup>+</sup> NK cells are associated with the disease activity and severity of systemic lupus erythematosus.","description":"It is well established that natural killer (NK) cells are dysregulated in systemic lupus erythematosus (SLE) patients. However, the functions of NK cells and the mechanisms regulated by them in SLE remain incompletely understood. Patients with SLE were recruited from The First Affiliated Hospital of Nanchang University, and their clinical characteristics and treatments were recorded. The expression levels of T cell immunoglobulin mucin-3 (TIM-3) and programmed cell death protein 1 (PD-1) on NK cells were examined using flow cytometry. The correlations between the increase in TIM-3<sup>+</sup>PD-1<sup>+</sup> NK cells in the SLE patients and clinical traits, including inflammatory markers, auto-antibodies, disease activity and severity of SLE, were examined. The TIM-3<sup>+</sup>NK cells, P","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2026-03-16T09:24:04.929Z","creation":"2025-08-15T03:06:58.278Z"},"accession":"S-EPMC8863699","cross_references":{"pubmed":["34101055"],"doi":["10.1007/s10238-021-00726-8"]}}