{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Anthony D"],"funding":["Directorate for Mathematical and Physical Sciences","Alfred P. Sloan Foundation","NIH HHS","NIGMS NIH HHS"],"pagination":["3198-3202"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8864584"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["58(10)"],"pubmed_abstract":["A nickel-catalyzed asymmetric diarylation reaction of vinylarenes enables the preparation of chiral α,α,β-triarylated ethane scaffolds, which exist in a number of biologically active molecules. The use of reducing conditions with aryl bromides as coupling partners obviates the need for stoichiometric organometallic reagents and tolerates a broad range of functional groups. The application of an N-oxyl radical as a ligand to a nickel catalyst represents a novel approach to facilitate nickel-catalyzed cross-coupling reactions."],"journal":["Angewandte Chemie (International ed. in English)"],"pubmed_title":["Nickel-Catalyzed Asymmetric Reductive Diarylation of Vinylarenes."],"pmcid":["PMC8864584"],"funding_grant_id":["FG-2018-10354","R01 GM127778","S10 OD016343","DMR-1420073"],"pubmed_authors":["Anthony D","Lin Q","Baudet J","Diao T"],"additional_accession":[]},"is_claimable":false,"name":"Nickel-Catalyzed Asymmetric Reductive Diarylation of Vinylarenes.","description":"A nickel-catalyzed asymmetric diarylation reaction of vinylarenes enables the preparation of chiral α,α,β-triarylated ethane scaffolds, which exist in a number of biologically active molecules. The use of reducing conditions with aryl bromides as coupling partners obviates the need for stoichiometric organometallic reagents and tolerates a broad range of functional groups. The application of an N-oxyl radical as a ligand to a nickel catalyst represents a novel approach to facilitate nickel-catalyzed cross-coupling reactions.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Mar","modification":"2025-04-19T13:19:23.679Z","creation":"2025-02-18T23:36:37.397Z"},"accession":"S-EPMC8864584","cross_references":{"pubmed":["30681765"],"doi":["10.1002/anie.201900228"]}}