biostudies-literatureLum SHWellcome Trust1319-1328https://www.ebi.ac.uk/biostudies/studies/S-EPMC8864655biostudies-literatureUnknown6(4)Hematopoietic cell transplantation (HCT) has become standard-of-care for an increasing number of inborn errors of immunity (IEI). This report is the first to compare transplant outcomes according to T-cell-replete (ie, T-replete) HLA-matched grafts using alemtuzumab (n = 117) and T-cell-depleted (ie, T-depleted) HLA-mismatched grafts using T-cell receptor-αβ (TCRαβ)/CD19 depletion (n = 47) in children with IEI who underwent first HCT between 2014 and 2019. All patients received treosulfan-based conditioning except patients with DNA repair disorders. For T-replete grafts, the stem cell source was marrow in 25 (21%) patients, peripheral blood stem cell (PBSC) in 85 (73%), and cord blood in 7 (6%). TCRαβ/CD19 depletion was performed on PBSCs from 45 haploidentical parental donors and 2 mismatBlood advancesT-replete HLA-matched grafts vs T-depleted HLA-mismatched grafts in inborn errors of immunity.PMC8864655204721/Z/16/ZLeahy TRLum SHJanuary RGennery ARWilliams ECarruthers KOwens SPerez-Heras IAbinun MWatson HSlatter MGreener SPayne RPHambleton SNademi ZWaugh SCant ADrozdov DFlood TBurton-Fanning SfalseT-replete HLA-matched grafts vs T-depleted HLA-mismatched grafts in inborn errors of immunity.Hematopoietic cell transplantation (HCT) has become standard-of-care for an increasing number of inborn errors of immunity (IEI). This report is the first to compare transplant outcomes according to T-cell-replete (ie, T-replete) HLA-matched grafts using alemtuzumab (n = 117) and T-cell-depleted (ie, T-depleted) HLA-mismatched grafts using T-cell receptor-αβ (TCRαβ)/CD19 depletion (n = 47) in children with IEI who underwent first HCT between 2014 and 2019. All patients received treosulfan-based conditioning except patients with DNA repair disorders. For T-replete grafts, the stem cell source was marrow in 25 (21%) patients, peripheral blood stem cell (PBSC) in 85 (73%), and cord blood in 7 (6%). TCRαβ/CD19 depletion was performed on PBSCs from 45 haploidentical parental donors and 2 mismat2022-01-01T00:00:00Z2022 Feb2026-05-31T05:00:12.918Z2025-08-21T09:50:29.38ZS-EPMC88646553497221210.1182/bloodadvances.2020004072