{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Naveca FG"],"funding":["LNCC","MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)","Fundação de Amparo à Pesquisa e Inovação do Espírito Santo (FAPES)","WHO | Pan American Health Organization (PAHO)","WHO | Pan American Health Organization","Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM)","Fundação de Amparo à Pesquisa e Inovação do Espírito Santo","Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)","MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico","Fundação Oswaldo Cruz","Fundação Oswaldo Cruz (FIOCRUZ)","Fundação de Amparo à Pesquisa do Estado do Amazonas","Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro"],"pagination":["e0236621"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8865440"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["The Amazonas was one of the most heavily affected Brazilian states by the COVID-19 epidemic. Despite a large number of infected people, particularly during the second wave associated with the spread of the Variant of Concern (VOC) Gamma (lineage P.1), SARS-CoV-2 continues to circulate in the Amazonas. To understand how SARS-CoV-2 persisted in a human population with a high immunity barrier, we generated 1,188 SARS-CoV-2 whole-genome sequences from individuals diagnosed in the Amazonas state from 1st January to 6th July 2021, of which 38 were vaccine breakthrough infections. Our study reveals a sharp increase in the relative prevalence of Gamma plus (P.1+) variants, designated Pango Lineages P.1.3 to P.1.6, harboring two types of additional Spike changes: deletions in the N-terminal (NTD) d"],"journal":["Microbiology spectrum"],"pubmed_title":["Spread of Gamma (P.1) Sub-Lineages Carrying Spike Mutations Close to the Furin Cleavage Site and Deletions in the N-Terminal Domain Drives Ongoing Transmission of SARS-CoV-2 in Amazonas, Brazil."],"pmcid":["PMC8865440"],"funding_grant_id":["de","E-26/202.896/2018","mica de Vigilâ","VPPCB-007-FIO-18-2-30","157/2021","403276/2020-9","ncia em Saú","PCTI-EmergeSaude","Rede Genô"],"pubmed_authors":["Martins A","Costa A","Naveca FG","Corado AL","Mejia MC","Bello G","Fiocruz COVID-19 Genomic Surveillance Network","Pessoa K","Dos Santos ER","Resende PC","de Melo GC","Miyajima F","Mourao MP","Dabilla N","Xavier MS","Batista ELR","Nascimento V","Brandao MJ","Goncalves L","Sampaio VS","Coelho D","Ferraz M","Abdalla L","Dias FBS","Lacerda MV","Siqueira MM","Wallau GL","Nascimento F","Souza V","Jesus M","Vinhal F","Fernandes C","Silva G","Mattos T","Santos JH","Chui FM","Val FF","Magalhaes ALA","Graf T","Delatorre E","Duarte D","Pereira LCG","Lins R"],"additional_accession":[]},"is_claimable":false,"name":"Spread of Gamma (P.1) Sub-Lineages Carrying Spike Mutations Close to the Furin Cleavage Site and Deletions in the N-Terminal Domain Drives Ongoing Transmission of SARS-CoV-2 in Amazonas, Brazil.","description":"The Amazonas was one of the most heavily affected Brazilian states by the COVID-19 epidemic. Despite a large number of infected people, particularly during the second wave associated with the spread of the Variant of Concern (VOC) Gamma (lineage P.1), SARS-CoV-2 continues to circulate in the Amazonas. To understand how SARS-CoV-2 persisted in a human population with a high immunity barrier, we generated 1,188 SARS-CoV-2 whole-genome sequences from individuals diagnosed in the Amazonas state from 1st January to 6th July 2021, of which 38 were vaccine breakthrough infections. Our study reveals a sharp increase in the relative prevalence of Gamma plus (P.1+) variants, designated Pango Lineages P.1.3 to P.1.6, harboring two types of additional Spike changes: deletions in the N-terminal (NTD) d","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2026-06-07T06:02:46.182Z","creation":"2025-05-29T20:10:57.361Z"},"accession":"S-EPMC8865440","cross_references":{"pubmed":["35196783"],"doi":["10.1128/spectrum.02366-21"]}}