{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Barzegaran E"],"funding":["Swiss National Science Foundation"],"pagination":["e3001534"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8865670"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(2)"],"pubmed_abstract":["Visual stimuli evoke fast-evolving activity patterns that are distributed across multiple cortical areas. These areas are hierarchically structured, as indicated by their anatomical projections, but how large-scale feedforward and feedback streams are functionally organized in this system remains an important missing clue to understanding cortical processing. By analyzing visual evoked responses in laminar recordings from 6 cortical areas in awake mice, we uncovered a dominant feedforward network with scale-free interactions in the time domain. In addition, we established the simultaneous presence of a gamma band feedforward and 2 low frequency feedback networks, each with a distinct laminar functional connectivity profile, frequency spectrum, temporal dynamics, and functional hierarchy. We could identify distinct roles for each of these 4 processing streams, by leveraging stimulus contrast effects, analyzing receptive field (RF) convergency along functional interactions, and determining relationships to spiking activity. Our results support a dynamic dual counterstream view of hierarchical processing and provide new insight into how separate functional streams can simultaneously and dynamically support visual processes."],"journal":["PLoS biology"],"pubmed_title":["Four concurrent feedforward and feedback networks with different roles in the visual cortical hierarchy."],"pmcid":["PMC8865670"],"funding_grant_id":["PP00P1_157420","PP00P1_183714"],"pubmed_authors":["Plomp G","Barzegaran E"],"additional_accession":[]},"is_claimable":false,"name":"Four concurrent feedforward and feedback networks with different roles in the visual cortical hierarchy.","description":"Visual stimuli evoke fast-evolving activity patterns that are distributed across multiple cortical areas. These areas are hierarchically structured, as indicated by their anatomical projections, but how large-scale feedforward and feedback streams are functionally organized in this system remains an important missing clue to understanding cortical processing. By analyzing visual evoked responses in laminar recordings from 6 cortical areas in awake mice, we uncovered a dominant feedforward network with scale-free interactions in the time domain. In addition, we established the simultaneous presence of a gamma band feedforward and 2 low frequency feedback networks, each with a distinct laminar functional connectivity profile, frequency spectrum, temporal dynamics, and functional hierarchy. We could identify distinct roles for each of these 4 processing streams, by leveraging stimulus contrast effects, analyzing receptive field (RF) convergency along functional interactions, and determining relationships to spiking activity. Our results support a dynamic dual counterstream view of hierarchical processing and provide new insight into how separate functional streams can simultaneously and dynamically support visual processes.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-04T08:41:05.143Z","creation":"2025-04-04T08:41:05.143Z"},"accession":"S-EPMC8865670","cross_references":{"pubmed":["35143472"],"doi":["10.1371/journal.pbio.3001534"]}}