{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Xu J"],"pubmed_abstract":["<h4>Background</h4>Acute kidney injury (AKI) is a clinical emergency characterized by a dramatic decline in renal function and the accumulation of metabolic waste products in the body, with a high morbidity and mortality rate. The pathogenesis of AKI remains unclear and there are no effective treatment options.<h4>Methods</h4>We aimed to identify critical genes involved in the pathogenesis of AKI and construct a miRNA-mRNA regulatory network using gene expression data downloaded from Gene Expression Omnibus (GSE85957) for 38 kidneys of AKI and 19 control rats and cisplatin treated kidneys of 3 AKI and 3 control rats. Data in GSE85957 were processed using weighted gene co-expression network analysis (WGCNA), and biological function analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG)"],"journal":["International journal of general medicine"],"pagination":["1853-1864"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8865863"],"repository":["biostudies-literature"],"pubmed_title":["Identifying of miRNA-mRNA Regulatory Networks Associated with Acute Kidney Injury by Weighted Gene Co-Expression Network Analysis."],"pmcid":["PMC8865863"],"pubmed_authors":["Xu J","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"Identifying of miRNA-mRNA Regulatory Networks Associated with Acute Kidney Injury by Weighted Gene Co-Expression Network Analysis.","description":"<h4>Background</h4>Acute kidney injury (AKI) is a clinical emergency characterized by a dramatic decline in renal function and the accumulation of metabolic waste products in the body, with a high morbidity and mortality rate. The pathogenesis of AKI remains unclear and there are no effective treatment options.<h4>Methods</h4>We aimed to identify critical genes involved in the pathogenesis of AKI and construct a miRNA-mRNA regulatory network using gene expression data downloaded from Gene Expression Omnibus (GSE85957) for 38 kidneys of AKI and 19 control rats and cisplatin treated kidneys of 3 AKI and 3 control rats. Data in GSE85957 were processed using weighted gene co-expression network analysis (WGCNA), and biological function analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG)","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-05-18T12:32:45.097Z","creation":"2025-05-18T12:32:45.097Z"},"accession":"S-EPMC8865863","cross_references":{"pubmed":["35221717"],"doi":["10.2147/IJGM.S353484"]}}