{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huang H"],"funding":["National Key R&amp;D Program of China","National Key R&D Program of China","Tianjin Science and Technology Plan Innovation Platform Special Support Program","National Natural Science Foundation of China"],"pagination":["95"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8867652"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["<h4>Background</h4>The promising therapeutic strategy for the treatment of peripheral artery disease (PAD) is to restore blood supply and promote regeneration of skeletal muscle regeneration. Increasing evidence revealed that prostaglandin E<sub>2</sub> (PGE<sub>2</sub>), a lipid signaling molecule, has significant therapeutic potential for tissue repair and regeneration. Though PGE<sub>2</sub> has been well reported in tissue regeneration, the application of PGE<sub>2</sub> is hampered by its short half-life in vivo and the lack of a viable system for sustained release of PGE<sub>2</sub>.<h4>Results</h4>In this study, we designed and synthesized a new PGE<sub>2</sub> release matrix by chemically bonding PGE<sub>2</sub> to collagen. Our results revealed that the PGE<sub>2</sub> matrix effe"],"journal":["Journal of nanobiotechnology"],"pubmed_title":["The sustained PGE<sub>2</sub> release matrix improves neovascularization and skeletal muscle regeneration in a hindlimb ischemia model."],"pmcid":["PMC8867652"],"funding_grant_id":["18PTSYJC00070","2017YFA0103200","U2004126"],"pubmed_authors":["Guo Z","Zhang J","Cao J","Huang H","Du W","Han Z","Chang Y","Han ZC","Li Z","Hua G","Benkirane-Jessel N","Chen S","Cheng H","Shen X"],"additional_accession":[]},"is_claimable":false,"name":"The sustained PGE<sub>2</sub> release matrix improves neovascularization and skeletal muscle regeneration in a hindlimb ischemia model.","description":"<h4>Background</h4>The promising therapeutic strategy for the treatment of peripheral artery disease (PAD) is to restore blood supply and promote regeneration of skeletal muscle regeneration. Increasing evidence revealed that prostaglandin E<sub>2</sub> (PGE<sub>2</sub>), a lipid signaling molecule, has significant therapeutic potential for tissue repair and regeneration. Though PGE<sub>2</sub> has been well reported in tissue regeneration, the application of PGE<sub>2</sub> is hampered by its short half-life in vivo and the lack of a viable system for sustained release of PGE<sub>2</sub>.<h4>Results</h4>In this study, we designed and synthesized a new PGE<sub>2</sub> release matrix by chemically bonding PGE<sub>2</sub> to collagen. Our results revealed that the PGE<sub>2</sub> matrix effe","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-04T13:21:37.877Z","creation":"2025-04-04T13:21:37.877Z"},"accession":"S-EPMC8867652","cross_references":{"pubmed":["35209908"],"doi":["10.1186/s12951-022-01301-3"]}}