{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zadoroznyj A"],"funding":["Conseil Régional de Bourgogne-Franche-Comté","Agence Nationale de la Recherche","Ligue contre le cancer, Comité de Côte d'Or"],"pagination":["322"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8869227"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(2)"],"pubmed_abstract":["Cellular inhibitor of apoptosis 1 (cIAP1) is a cell signaling regulator of the IAP family. Through its E3-ubiquitine ligase activity, it has the ability to activate intracellular signaling pathways, modify signal transduction pathways by changing protein-protein interaction networks, and stop signal transduction by promoting the degradation of critical components of signaling pathways. Thus, cIAP1 appears to be a potent determinant of the response of cells, enabling their rapid adaptation to changing environmental conditions or intra- or extracellular stresses. It is expressed in almost all tissues, found in the cytoplasm, membrane and/or nucleus of cells. cIAP1 regulates innate immunity by controlling signaling pathways mediated by tumor necrosis factor receptor superfamily (TNFRs), some "],"journal":["Biomolecules"],"pubmed_title":["Cytoplasmic and Nuclear Functions of cIAP1."],"pmcid":["PMC8869227"],"funding_grant_id":["ANR-11-LABX-0021","x"],"pubmed_authors":["Zadoroznyj A","Dubrez L"],"additional_accession":[]},"is_claimable":false,"name":"Cytoplasmic and Nuclear Functions of cIAP1.","description":"Cellular inhibitor of apoptosis 1 (cIAP1) is a cell signaling regulator of the IAP family. Through its E3-ubiquitine ligase activity, it has the ability to activate intracellular signaling pathways, modify signal transduction pathways by changing protein-protein interaction networks, and stop signal transduction by promoting the degradation of critical components of signaling pathways. Thus, cIAP1 appears to be a potent determinant of the response of cells, enabling their rapid adaptation to changing environmental conditions or intra- or extracellular stresses. It is expressed in almost all tissues, found in the cytoplasm, membrane and/or nucleus of cells. cIAP1 regulates innate immunity by controlling signaling pathways mediated by tumor necrosis factor receptor superfamily (TNFRs), some ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-05-18T12:31:51.657Z","creation":"2025-04-04T23:29:18.728Z"},"accession":"S-EPMC8869227","cross_references":{"pubmed":["35204822"],"doi":["10.3390/biom12020322"]}}