biostudies-literatureZadoroznyj AConseil Régional de Bourgogne-Franche-ComtéAgence Nationale de la RechercheLigue contre le cancer, Comité de Côte d'Or322https://www.ebi.ac.uk/biostudies/studies/S-EPMC8869227biostudies-literatureUnknown12(2)Cellular inhibitor of apoptosis 1 (cIAP1) is a cell signaling regulator of the IAP family. Through its E3-ubiquitine ligase activity, it has the ability to activate intracellular signaling pathways, modify signal transduction pathways by changing protein-protein interaction networks, and stop signal transduction by promoting the degradation of critical components of signaling pathways. Thus, cIAP1 appears to be a potent determinant of the response of cells, enabling their rapid adaptation to changing environmental conditions or intra- or extracellular stresses. It is expressed in almost all tissues, found in the cytoplasm, membrane and/or nucleus of cells. cIAP1 regulates innate immunity by controlling signaling pathways mediated by tumor necrosis factor receptor superfamily (TNFRs), some BiomoleculesCytoplasmic and Nuclear Functions of cIAP1.PMC8869227ANR-11-LABX-0021xZadoroznyj ADubrez LfalseCytoplasmic and Nuclear Functions of cIAP1.Cellular inhibitor of apoptosis 1 (cIAP1) is a cell signaling regulator of the IAP family. Through its E3-ubiquitine ligase activity, it has the ability to activate intracellular signaling pathways, modify signal transduction pathways by changing protein-protein interaction networks, and stop signal transduction by promoting the degradation of critical components of signaling pathways. Thus, cIAP1 appears to be a potent determinant of the response of cells, enabling their rapid adaptation to changing environmental conditions or intra- or extracellular stresses. It is expressed in almost all tissues, found in the cytoplasm, membrane and/or nucleus of cells. cIAP1 regulates innate immunity by controlling signaling pathways mediated by tumor necrosis factor receptor superfamily (TNFRs), some 2022-01-01T00:00:00Z2022 Feb2025-05-18T12:31:51.657Z2025-04-04T23:29:18.728ZS-EPMC88692273520482210.3390/biom12020322