{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kuribara T"],"funding":["Japan Society for the Promotion of Science"],"pagination":["199"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8869290"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(2)"],"pubmed_abstract":["Glycoprotein folding plays a critical role in sorting glycoprotein secretion and degradation in the endoplasmic reticulum (ER). Furthermore, relationships between glycoprotein folding and several diseases, such as type 2 diabetes and various neurodegenerative disorders, are indicated. Patients' cells with type 2 diabetes, and various neurodegenerative disorders induce ER stress, against which the cells utilize the unfolded protein response for protection. However, in some cases, chronic and/or massive ER stress causes critical damage to cells, leading to the onset of ER stress-related diseases, which are categorized into misfolding diseases. Accumulation of misfolded proteins may be a cause of ER stress, in this respect, perturbation of oligomannose-type glycan processing in the ER may occ"],"journal":["Biology"],"pubmed_title":["Oligomannose-Type Glycan Processing in the Endoplasmic Reticulum and Its Importance in Misfolding Diseases."],"pmcid":["PMC8869290"],"funding_grant_id":["JP16K01938","JP16H06290"],"pubmed_authors":["Kuribara T","Totani K"],"additional_accession":[]},"is_claimable":false,"name":"Oligomannose-Type Glycan Processing in the Endoplasmic Reticulum and Its Importance in Misfolding Diseases.","description":"Glycoprotein folding plays a critical role in sorting glycoprotein secretion and degradation in the endoplasmic reticulum (ER). Furthermore, relationships between glycoprotein folding and several diseases, such as type 2 diabetes and various neurodegenerative disorders, are indicated. Patients' cells with type 2 diabetes, and various neurodegenerative disorders induce ER stress, against which the cells utilize the unfolded protein response for protection. However, in some cases, chronic and/or massive ER stress causes critical damage to cells, leading to the onset of ER stress-related diseases, which are categorized into misfolding diseases. Accumulation of misfolded proteins may be a cause of ER stress, in this respect, perturbation of oligomannose-type glycan processing in the ER may occ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-22T01:27:22.871Z","creation":"2025-04-05T19:57:21.737Z"},"accession":"S-EPMC8869290","cross_references":{"pubmed":["35205066"],"doi":["10.3390/biology11020199"]}}