{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rastoldo G"],"funding":["the Ministère de l’Enseignement Supérieur et de la Recherche and CNRS, Programme Investissements d’Avenir, Initiative d’Excellence d’Aix-Marseille Université"],"pagination":["684"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8869897"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(4)"],"pubmed_abstract":["Unilateral vestibular lesions induce a vestibular syndrome, which recovers over time due to vestibular compensation. The therapeutic effect of L-Thyroxine (L-T4) on vestibular compensation was investigated by behavioral testing and immunohistochemical analysis in a rat model of unilateral vestibular neurectomy (UVN). We demonstrated that a short-term L-T4 treatment reduced the vestibular syndrome and significantly promoted vestibular compensation. Thyroid hormone receptors (TRα and TRβ) and type II iodothyronine deiodinase (DIO2) were present in the vestibular nuclei (VN), supporting a local action of L-T4. We confirmed the T4-induced metabolic effects by demonstrating an increase in the number of cytochrome oxidase-labeled neurons in the VN three days after the lesion. L-T4 treatment modu"],"journal":["Cells"],"pubmed_title":["L-Thyroxine Improves Vestibular Compensation in a Rat Model of Acute Peripheral Vestibulopathy: Cellular and Behavioral Aspects."],"pmcid":["PMC8869897"],"funding_grant_id":["AMX-19-IET-004 and ANR-17-EURE-0029"],"pubmed_authors":["Caron P","Pericat D","El-Ahmadi A","Fraysse ME","Rastoldo G","Tonetto A","Marouane E","Lapotre A","Tighilet B","Lopez-Juarez A","Chabbert C","Zwergal A","Watabe I","El-Mahmoudi N"],"additional_accession":[]},"is_claimable":false,"name":"L-Thyroxine Improves Vestibular Compensation in a Rat Model of Acute Peripheral Vestibulopathy: Cellular and Behavioral Aspects.","description":"Unilateral vestibular lesions induce a vestibular syndrome, which recovers over time due to vestibular compensation. The therapeutic effect of L-Thyroxine (L-T4) on vestibular compensation was investigated by behavioral testing and immunohistochemical analysis in a rat model of unilateral vestibular neurectomy (UVN). We demonstrated that a short-term L-T4 treatment reduced the vestibular syndrome and significantly promoted vestibular compensation. Thyroid hormone receptors (TRα and TRβ) and type II iodothyronine deiodinase (DIO2) were present in the vestibular nuclei (VN), supporting a local action of L-T4. We confirmed the T4-induced metabolic effects by demonstrating an increase in the number of cytochrome oxidase-labeled neurons in the VN three days after the lesion. L-T4 treatment modu","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-22T19:14:29.023Z","creation":"2024-11-12T16:33:29.05Z"},"accession":"S-EPMC8869897","cross_references":{"pubmed":["35203333"],"doi":["10.3390/cells11040684"]}}