biostudies-literatureRastoldo Gthe Ministère de l’Enseignement Supérieur et de la Recherche and CNRS, Programme Investissements d’Avenir, Initiative d’Excellence d’Aix-Marseille Université684https://www.ebi.ac.uk/biostudies/studies/S-EPMC8869897biostudies-literatureUnknown11(4)Unilateral vestibular lesions induce a vestibular syndrome, which recovers over time due to vestibular compensation. The therapeutic effect of L-Thyroxine (L-T4) on vestibular compensation was investigated by behavioral testing and immunohistochemical analysis in a rat model of unilateral vestibular neurectomy (UVN). We demonstrated that a short-term L-T4 treatment reduced the vestibular syndrome and significantly promoted vestibular compensation. Thyroid hormone receptors (TRα and TRβ) and type II iodothyronine deiodinase (DIO2) were present in the vestibular nuclei (VN), supporting a local action of L-T4. We confirmed the T4-induced metabolic effects by demonstrating an increase in the number of cytochrome oxidase-labeled neurons in the VN three days after the lesion. L-T4 treatment moduCellsL-Thyroxine Improves Vestibular Compensation in a Rat Model of Acute Peripheral Vestibulopathy: Cellular and Behavioral Aspects.PMC8869897AMX-19-IET-004 and ANR-17-EURE-0029Caron PPericat DEl-Ahmadi AFraysse MERastoldo GTonetto AMarouane ELapotre ATighilet BLopez-Juarez AChabbert CZwergal AWatabe IEl-Mahmoudi NfalseL-Thyroxine Improves Vestibular Compensation in a Rat Model of Acute Peripheral Vestibulopathy: Cellular and Behavioral Aspects.Unilateral vestibular lesions induce a vestibular syndrome, which recovers over time due to vestibular compensation. The therapeutic effect of L-Thyroxine (L-T4) on vestibular compensation was investigated by behavioral testing and immunohistochemical analysis in a rat model of unilateral vestibular neurectomy (UVN). We demonstrated that a short-term L-T4 treatment reduced the vestibular syndrome and significantly promoted vestibular compensation. Thyroid hormone receptors (TRα and TRβ) and type II iodothyronine deiodinase (DIO2) were present in the vestibular nuclei (VN), supporting a local action of L-T4. We confirmed the T4-induced metabolic effects by demonstrating an increase in the number of cytochrome oxidase-labeled neurons in the VN three days after the lesion. L-T4 treatment modu2022-01-01T00:00:00Z2022 Feb2025-04-22T19:14:29.023Z2024-11-12T16:33:29.05ZS-EPMC88698973520333310.3390/cells11040684