biostudies-literatureBusek MEuropean UnionThe Research Council of Norway126https://www.ebi.ac.uk/biostudies/studies/S-EPMC8869899biostudies-literatureUnknown12(2)Organ-on-a-Chip (OoC) systems bring together cell biology, engineering, and material science for creating systems that recapitulate the in vivo microenvironment of tissues and organs. The versatility of OoC systems enables in vitro models for studying physiological processes, drug development, and testing in both academia and industry. This paper evaluates current platforms from the academic end-user perspective, elaborating on usability, complexity, and robustness. We surveyed 187 peers in 35 countries and grouped the responses according to preliminary knowledge and the source of the OoC systems that are used. The survey clearly shows that current commercial OoC platforms provide a substantial level of robustness and usability-which is also indicated by an increasing adaptation of the phaBiosensorsAcademic User View: Organ-on-a-Chip Technology.PMC8869899Marie Skłodowska-Curie Actions Grant agreement No 801133Centers of Excellence scheme, project number 262613Delon LBusek MKrauss SAizenshtadt AAmirola-Martinez MfalseAcademic User View: Organ-on-a-Chip Technology.Organ-on-a-Chip (OoC) systems bring together cell biology, engineering, and material science for creating systems that recapitulate the in vivo microenvironment of tissues and organs. The versatility of OoC systems enables in vitro models for studying physiological processes, drug development, and testing in both academia and industry. This paper evaluates current platforms from the academic end-user perspective, elaborating on usability, complexity, and robustness. We surveyed 187 peers in 35 countries and grouped the responses according to preliminary knowledge and the source of the OoC systems that are used. The survey clearly shows that current commercial OoC platforms provide a substantial level of robustness and usability-which is also indicated by an increasing adaptation of the pha2022-01-01T00:00:00Z2022 Feb2025-04-25T22:30:04.556Z2025-02-19T03:47:02.581ZS-EPMC88698993520038610.3390/bios12020126