biostudies-literatureUnknown17(2)Agirbasli DVitamin D deficiency is common among postmenopausal women. Telomere length can be a potential protective mechanism for age-related diseases. The objective of our study is to examine the association of vitamin D supplementation on leukocyte telomere length (LTL) in healthy postmenopausal women with vitamin D deficiency. The study was designed as a placebo-controlled study to investigate the short-term effects of vitamin D supplementation and seasonal changes on vitamin D related parameters, including 25(OH)D, 1,25(OH)2D parathormone (PTH), Vitamin D binding protein (VDBP), vitamin D receptor (VDR), and telomere length in a cohort of postmenopausal women (n = 102). The group was divided as supplementation (n = 52) and placebo groups (n = 50). All parameters were measured before and after trePloS onee0264337https://www.ebi.ac.uk/biostudies/studies/S-EPMC8870535biostudies-literatureLeukocyte telomere length as a compensatory mechanism in vitamin D metabolism.PMC8870535Aksungar FBAgirbasli DMuftuoglu MKalyoncu MAgirbasli MfalseLeukocyte telomere length as a compensatory mechanism in vitamin D metabolism.Vitamin D deficiency is common among postmenopausal women. Telomere length can be a potential protective mechanism for age-related diseases. The objective of our study is to examine the association of vitamin D supplementation on leukocyte telomere length (LTL) in healthy postmenopausal women with vitamin D deficiency. The study was designed as a placebo-controlled study to investigate the short-term effects of vitamin D supplementation and seasonal changes on vitamin D related parameters, including 25(OH)D, 1,25(OH)2D parathormone (PTH), Vitamin D binding protein (VDBP), vitamin D receptor (VDR), and telomere length in a cohort of postmenopausal women (n = 102). The group was divided as supplementation (n = 52) and placebo groups (n = 50). All parameters were measured before and after tre2022-01-01T00:00:00Z20222025-04-21T23:11:01.928Z2025-04-05T19:06:43.074ZS-EPMC88705353520241810.1371/journal.pone.0264337