{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Woerner J"],"funding":["U.S. Department of Health & Human Services | NIH | U.S. National Library of Medicine","Torsten Haferlach Leukamiediagnostik Stiftung","U.S. Department of Health & Human Services | NIH | National Cancer Institute","NLM NIH HHS","NCI NIH HHS"],"pagination":["1038"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8873459"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Although recent work has described the microbiome in solid tumors, microbial content in hematological malignancies is not well-characterized. Here we analyze existing deep DNA sequence data from the blood and bone marrow of 1870 patients with myeloid malignancies, along with healthy controls, for bacterial, fungal, and viral content. After strict quality filtering, we find evidence for dysbiosis in disease cases, and distinct microbial signatures among disease subtypes. We also find that microbial content is associated with host gene mutations and with myeloblast cell percentages. In patients with low-risk myelodysplastic syndrome, we provide evidence that Epstein-Barr virus status refines risk stratification into more precise categories than the current standard. Motivated by these observ"],"journal":["Nature communications"],"pubmed_title":["Circulating microbial content in myeloid malignancy patients is associated with disease subtypes and patient outcomes."],"pmcid":["PMC8873459"],"funding_grant_id":["R01 CA217992","R01 CA257544","R21 CA249138","R01LM013067","R01CA257544","R01CA217992","R01 LM013067","R21CA249138"],"pubmed_authors":["Sanchez JMH","Thorat V","Koyuturk M","Schnabel D","Jha BK","Wang J","Haferlach T","Huang Y","Aaby M","Jiang D","Gurnari C","Xu W","Maciejewski JP","LaFramboise T","Woerner J","Hutter S"],"additional_accession":[]},"is_claimable":false,"name":"Circulating microbial content in myeloid malignancy patients is associated with disease subtypes and patient outcomes.","description":"Although recent work has described the microbiome in solid tumors, microbial content in hematological malignancies is not well-characterized. Here we analyze existing deep DNA sequence data from the blood and bone marrow of 1870 patients with myeloid malignancies, along with healthy controls, for bacterial, fungal, and viral content. After strict quality filtering, we find evidence for dysbiosis in disease cases, and distinct microbial signatures among disease subtypes. We also find that microbial content is associated with host gene mutations and with myeloblast cell percentages. In patients with low-risk myelodysplastic syndrome, we provide evidence that Epstein-Barr virus status refines risk stratification into more precise categories than the current standard. Motivated by these observ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2026-03-31T10:58:11.288Z","creation":"2025-09-01T03:05:37.548Z"},"accession":"S-EPMC8873459","cross_references":{"pubmed":["35210415"],"doi":["10.1038/s41467-022-28678-x"]}}