biostudies-literatureUnknown17(1)Song D<h4>Purpose</h4>Smurf2, one of C2-WW-HECT domain E3 ubiquitin ligases, is closely related to the development and progression in different cancer types, including hepatocellular carcinoma (HCC). This study aims to illustrate the expression and molecular mechanism of Smurf2 in regulating the progression of HCC.<h4>Methods</h4>The expression of Smurf2 in human HCC and adjacent non-tumor liver specimens was detected using tissue microarray studies from 220 HCC patients who underwent curative resection. The relationships of Smurf2 and HCC progression and survival were analyzed using the chi-square test, Kaplan-Meier analysis, and Cox proportional hazards model. For Smurf2 was low expression in HCC cell lines, Smurf2 overexpression cell lines were established. The effect of Smurf2 on cell prolifOpen medicine (Warsaw, Poland)384-396https://www.ebi.ac.uk/biostudies/studies/S-EPMC8874264biostudies-literatureSmurf2 suppresses the metastasis of hepatocellular carcinoma via ubiquitin degradation of Smad2.PMC8874264Li SNing LSong DCai YZhang SfalseSmurf2 suppresses the metastasis of hepatocellular carcinoma via ubiquitin degradation of Smad2.<h4>Purpose</h4>Smurf2, one of C2-WW-HECT domain E3 ubiquitin ligases, is closely related to the development and progression in different cancer types, including hepatocellular carcinoma (HCC). This study aims to illustrate the expression and molecular mechanism of Smurf2 in regulating the progression of HCC.<h4>Methods</h4>The expression of Smurf2 in human HCC and adjacent non-tumor liver specimens was detected using tissue microarray studies from 220 HCC patients who underwent curative resection. The relationships of Smurf2 and HCC progression and survival were analyzed using the chi-square test, Kaplan-Meier analysis, and Cox proportional hazards model. For Smurf2 was low expression in HCC cell lines, Smurf2 overexpression cell lines were established. The effect of Smurf2 on cell prolif2022-01-01T00:00:00Z20222025-04-04T09:41:13.53Z2025-04-04T09:41:13.53ZS-EPMC88742643550968810.1515/med-2022-0437