biostudies-literatureYunusa INIA NIH HHSAHRQ HHSNIAMS NIH HHSe220194https://www.ebi.ac.uk/biostudies/studies/S-EPMC8874341biostudies-literatureUnknown5(2)<h4>Importance</h4>Some selective serotonin reuptake inhibitors (SSRIs) inhibit the enzymes responsible for the metabolism of oxycodone, a potent prescription opioid. The clinical consequences of this interaction on the risk of opioid overdose have not been elucidated.<h4>Objective</h4>To compare opioid overdose rates in patients initiating oxycodone while taking SSRIs that are potent inhibitors of the cytochrome-P450 2D6 enzyme (CYP2D6) vs SSRIs that are not.<h4>Design, setting, and participants</h4>This cohort study included adults who initiated oxycodone while receiving SSRI therapy between 2000 and 2020 whose data were included in 3 US health insurance databases.<h4>Exposures</h4>Use of SSRIs that strongly inhibit CYP2D6 enzyme (fluoxetine or paroxetine) vs use of other SSRIs at the tiJAMA network openRisk of Opioid Overdose Associated With Concomitant Use of Oxycodone and Selective Serotonin Reuptake Inhibitors.PMC8874341K23 AR076453K01 AG068365R01 HS027623Gagne JJYunusa IBykov KYoshida KfalseRisk of Opioid Overdose Associated With Concomitant Use of Oxycodone and Selective Serotonin Reuptake Inhibitors.<h4>Importance</h4>Some selective serotonin reuptake inhibitors (SSRIs) inhibit the enzymes responsible for the metabolism of oxycodone, a potent prescription opioid. The clinical consequences of this interaction on the risk of opioid overdose have not been elucidated.<h4>Objective</h4>To compare opioid overdose rates in patients initiating oxycodone while taking SSRIs that are potent inhibitors of the cytochrome-P450 2D6 enzyme (CYP2D6) vs SSRIs that are not.<h4>Design, setting, and participants</h4>This cohort study included adults who initiated oxycodone while receiving SSRI therapy between 2000 and 2020 whose data were included in 3 US health insurance databases.<h4>Exposures</h4>Use of SSRIs that strongly inhibit CYP2D6 enzyme (fluoxetine or paroxetine) vs use of other SSRIs at the ti2022-01-01T00:00:00Z2022 Feb2025-04-04T12:44:09.936Z2025-04-04T12:44:09.936ZS-EPMC88743413520131010.1001/jamanetworkopen.2022.0194