{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pechere-Bertschi A"],"funding":["NCCR Kidney Control of  Homoeostasis","University Hospital Geneva","Swiss National Foundation and"],"pagination":["548-557"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8875469"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["37(3)"],"pubmed_abstract":["<h4>Background</h4>The effects of sodium (Na+) intakes on renal handling of potassium (K+) are insufficiently studied.<h4>Methods</h4>We assessed the effect of Na+ on renal K+ handling in 16 healthy males assigned to three 7-day periods on low salt diet [LSD, 3 g sodium chloride (NaCl)/day], normal salt diet (NSD, 6 g NaCl/day) and high salt diet (HSD, 15 g NaCl/day), with constant K+ intake. Contributions of distal NaCl co-transporter and epithelial Na+ channel in the collecting system on K+ and Na+ handling were assessed at steady state by acute response to 100 mg oral hydrochlorothiazide and with addition of 10 mg of amiloride to hydrochlorothiazide, respectively.<h4>Results</h4>Diurnal blood pressure slightly increased from 119.30 ± 7.95 mmHg under LSD to 123.00 ± 7.50 mmHg (P = 0.02) "],"journal":["Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association"],"pubmed_title":["Dietary sodium intake does not alter renal potassium handling and blood pressure in healthy young males."],"pmcid":["PMC8875469"],"funding_grant_id":["31003","A_175471/1)."],"pubmed_authors":["Udwan K","Ponte B","Maillard M","Burnier M","Martin PY","Pechere-Bertschi A","Feraille E","Olivier V","de Seigneux S"],"additional_accession":[]},"is_claimable":false,"name":"Dietary sodium intake does not alter renal potassium handling and blood pressure in healthy young males.","description":"<h4>Background</h4>The effects of sodium (Na+) intakes on renal handling of potassium (K+) are insufficiently studied.<h4>Methods</h4>We assessed the effect of Na+ on renal K+ handling in 16 healthy males assigned to three 7-day periods on low salt diet [LSD, 3 g sodium chloride (NaCl)/day], normal salt diet (NSD, 6 g NaCl/day) and high salt diet (HSD, 15 g NaCl/day), with constant K+ intake. Contributions of distal NaCl co-transporter and epithelial Na+ channel in the collecting system on K+ and Na+ handling were assessed at steady state by acute response to 100 mg oral hydrochlorothiazide and with addition of 10 mg of amiloride to hydrochlorothiazide, respectively.<h4>Results</h4>Diurnal blood pressure slightly increased from 119.30 ± 7.95 mmHg under LSD to 123.00 ± 7.50 mmHg (P = 0.02) ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-25T22:32:35.614Z","creation":"2025-04-06T09:04:43.919Z"},"accession":"S-EPMC8875469","cross_references":{"pubmed":["33492394"],"doi":["10.1093/ndt/gfaa381"]}}