biostudies-literaturePechere-Bertschi ANCCR Kidney Control of HomoeostasisUniversity Hospital GenevaSwiss National Foundation and548-557https://www.ebi.ac.uk/biostudies/studies/S-EPMC8875469biostudies-literatureUnknown37(3)<h4>Background</h4>The effects of sodium (Na+) intakes on renal handling of potassium (K+) are insufficiently studied.<h4>Methods</h4>We assessed the effect of Na+ on renal K+ handling in 16 healthy males assigned to three 7-day periods on low salt diet [LSD, 3 g sodium chloride (NaCl)/day], normal salt diet (NSD, 6 g NaCl/day) and high salt diet (HSD, 15 g NaCl/day), with constant K+ intake. Contributions of distal NaCl co-transporter and epithelial Na+ channel in the collecting system on K+ and Na+ handling were assessed at steady state by acute response to 100 mg oral hydrochlorothiazide and with addition of 10 mg of amiloride to hydrochlorothiazide, respectively.<h4>Results</h4>Diurnal blood pressure slightly increased from 119.30 ± 7.95 mmHg under LSD to 123.00 ± 7.50 mmHg (P = 0.02) Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal AssociationDietary sodium intake does not alter renal potassium handling and blood pressure in healthy young males.PMC887546931003A_175471/1).Udwan KPonte BMaillard MBurnier MMartin PYPechere-Bertschi AFeraille EOlivier Vde Seigneux SfalseDietary sodium intake does not alter renal potassium handling and blood pressure in healthy young males.<h4>Background</h4>The effects of sodium (Na+) intakes on renal handling of potassium (K+) are insufficiently studied.<h4>Methods</h4>We assessed the effect of Na+ on renal K+ handling in 16 healthy males assigned to three 7-day periods on low salt diet [LSD, 3 g sodium chloride (NaCl)/day], normal salt diet (NSD, 6 g NaCl/day) and high salt diet (HSD, 15 g NaCl/day), with constant K+ intake. Contributions of distal NaCl co-transporter and epithelial Na+ channel in the collecting system on K+ and Na+ handling were assessed at steady state by acute response to 100 mg oral hydrochlorothiazide and with addition of 10 mg of amiloride to hydrochlorothiazide, respectively.<h4>Results</h4>Diurnal blood pressure slightly increased from 119.30 ± 7.95 mmHg under LSD to 123.00 ± 7.50 mmHg (P = 0.02) 2022-01-01T00:00:00Z2022 Feb2025-04-25T22:32:35.614Z2025-04-06T09:04:43.919ZS-EPMC88754693349239410.1093/ndt/gfaa381