{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Qi S"],"funding":["National Natural Science Foundation of China"],"pagination":["174"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8877149"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(2)"],"pubmed_abstract":["Defensins are a class of cationic disulfide-bridged antimicrobial peptides (AMPs) present in many eukaryotic organisms and even in bacteria. They primarily include two distinct but evolutionarily related superfamilies (<i>cis</i> and <i>trans</i>). Defensins in fungi belong to the members of the <i>cis</i>-superfamily with the cysteine-stabilized α-helical and β-sheet fold. To date, many fungal defensin-like peptides (fDLPs) have been found through gene mining of the genome resource, but only a few have been experimentally characterized. Here, we report the structural and functional characterization of Pyronesin4 (abbreviated as Py4), a fDLP previously identified by genomic sequencing of the basal filamentous ascomycete <i>Pyronema confluens</i>. Chemically, synthetic Py4 adopts a native-l"],"journal":["Journal of fungi (Basel, Switzerland)"],"pubmed_title":["A Fungal Defensin Inhibiting Bacterial Cell-Wall Biosynthesis with Non-Hemolysis and Serum Stability."],"pmcid":["PMC8877149"],"funding_grant_id":["31870766"],"pubmed_authors":["Gao B","Qi S","Zhu S"],"additional_accession":[]},"is_claimable":false,"name":"A Fungal Defensin Inhibiting Bacterial Cell-Wall Biosynthesis with Non-Hemolysis and Serum Stability.","description":"Defensins are a class of cationic disulfide-bridged antimicrobial peptides (AMPs) present in many eukaryotic organisms and even in bacteria. They primarily include two distinct but evolutionarily related superfamilies (<i>cis</i> and <i>trans</i>). Defensins in fungi belong to the members of the <i>cis</i>-superfamily with the cysteine-stabilized α-helical and β-sheet fold. To date, many fungal defensin-like peptides (fDLPs) have been found through gene mining of the genome resource, but only a few have been experimentally characterized. Here, we report the structural and functional characterization of Pyronesin4 (abbreviated as Py4), a fDLP previously identified by genomic sequencing of the basal filamentous ascomycete <i>Pyronema confluens</i>. Chemically, synthetic Py4 adopts a native-l","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2026-04-08T17:21:32.531Z","creation":"2025-02-19T05:04:49.243Z"},"accession":"S-EPMC8877149","cross_references":{"pubmed":["35205928"],"doi":["10.3390/jof8020174"]}}