biostudies-literatureUnknown8(2)Skiada ACutaneous mucormycosis is the third most common clinical type of mucormycosis. The signs and symptoms vary widely, and it is important to make the diagnosis as early as possible in order to achieve a better outcome. We present a systematic review of its epidemiology, clinical presentation, diagnosis, and treatment, analyzing cases published from 1958 until 2021. The review was conducted according to the PRISMA guidelines and included 693 cases from 485 articles from 46 countries. Most publications were from North America (256 cases, 36.9%) and Asia (216 cases, 31.2%). The most common risk factors were diabetes mellitus (20%) and hematological malignancies (15.7%). However, a large proportion of published cases (275, 39.6%) had no identified underlying disease. The most common mode of transJournal of fungi (Basel, Switzerland)194https://www.ebi.ac.uk/biostudies/studies/S-EPMC8878367biostudies-literatureGlobal Cutaneous Mucormycosis: A Systematic Review.PMC8878367Skiada APavleas IDrogari-Apiranthitou MPetrikkos GDaikou EfalseGlobal Cutaneous Mucormycosis: A Systematic Review.Cutaneous mucormycosis is the third most common clinical type of mucormycosis. The signs and symptoms vary widely, and it is important to make the diagnosis as early as possible in order to achieve a better outcome. We present a systematic review of its epidemiology, clinical presentation, diagnosis, and treatment, analyzing cases published from 1958 until 2021. The review was conducted according to the PRISMA guidelines and included 693 cases from 485 articles from 46 countries. Most publications were from North America (256 cases, 36.9%) and Asia (216 cases, 31.2%). The most common risk factors were diabetes mellitus (20%) and hematological malignancies (15.7%). However, a large proportion of published cases (275, 39.6%) had no identified underlying disease. The most common mode of trans2022-01-01T00:00:00Z2022 Feb2025-04-19T00:38:28.391Z2025-04-07T11:42:14.735ZS-EPMC88783673520594810.3390/jof8020194