{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vidor CJ"],"funding":["Australian Research Council"],"pagination":["124"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8878733"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(2)"],"pubmed_abstract":["Protein secretion is generally mediated by a series of distinct pathways in bacteria. Recently, evidence of a novel bacterial secretion pathway involving a bacteriophage-related protein has emerged. TcdE, a holin-like protein encoded by toxigenic isolates of <i>Clostridioides difficile</i>, mediates the release of the large clostridial glucosylating toxins (LCGTs), TcdA and TcdB, and TpeL from <i>C. perfringens</i> uses another holin-like protein, TpeE, for its secretion; however, it is not yet known if TcdE or TpeE secretion is specific to these proteins. It is also unknown if other members of the LCGT-producing clostridia, including <i>Paeniclostridium sordellii</i> (previously <i>Clostridium sordellii</i>)<i>,</i> use a similar toxin-release mechanism. Here, we confirm that each of the "],"journal":["Toxins"],"pubmed_title":["A Highly Specific Holin-Mediated Mechanism Facilitates the Secretion of Lethal Toxin TcsL in <i>Paeniclostridium</i><i>sordellii</i>."],"pmcid":["PMC8878733"],"funding_grant_id":["FT120100779"],"pubmed_authors":["Mathias RA","Awad M","Lyras D","Dupuy B","Hamiot A","Wisniewski J","Vidor CJ"],"additional_accession":[]},"is_claimable":false,"name":"A Highly Specific Holin-Mediated Mechanism Facilitates the Secretion of Lethal Toxin TcsL in <i>Paeniclostridium</i><i>sordellii</i>.","description":"Protein secretion is generally mediated by a series of distinct pathways in bacteria. Recently, evidence of a novel bacterial secretion pathway involving a bacteriophage-related protein has emerged. TcdE, a holin-like protein encoded by toxigenic isolates of <i>Clostridioides difficile</i>, mediates the release of the large clostridial glucosylating toxins (LCGTs), TcdA and TcdB, and TpeL from <i>C. perfringens</i> uses another holin-like protein, TpeE, for its secretion; however, it is not yet known if TcdE or TpeE secretion is specific to these proteins. It is also unknown if other members of the LCGT-producing clostridia, including <i>Paeniclostridium sordellii</i> (previously <i>Clostridium sordellii</i>)<i>,</i> use a similar toxin-release mechanism. Here, we confirm that each of the ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2026-04-08T17:56:08.473Z","creation":"2024-11-13T18:13:05.615Z"},"accession":"S-EPMC8878733","cross_references":{"pubmed":["35202151"],"doi":["10.3390/toxins14020124"]}}