biostudies-literatureUnknown17(2)Lee HJ<h4>Background</h4>We aimed to clarify the sex differences in various cardiovascular and non-cardiovascular outcomes, and to investigate whether sex differences in outcomes are affected by age in hypertrophic cardiomyopathy (HCM).<h4>Methods</h4>A cohort of 835 patients with HCM initially evaluated during 2007-2019 were followed for a median of 6.4 years. Study outcomes were all-cause death, cardiovascular and non-cardiovascular death, sudden cardiac death (SCD)/SCD equivalent events, heart failure (HF) events, and the composite cardiovascular outcome including cardiovascular death, SCD/SCD equivalent events, admission for HF, and heart transplantation.<h4>Results</h4>Women were 5 years older (women 59.9±13.5 vs. men 54.9±11.4 years), had worse dyspnea, and greater left ventricular (LV) diPloS onee0264580https://www.ebi.ac.uk/biostudies/studies/S-EPMC8880392biostudies-literatureAge-related sex differences in the outcomes of patients with hypertrophic cardiomyopathy.PMC8880392Kim HKOmmen SRChang SAChoi YJKim YJLee SCLee HJKim JPark JBLee SPfalseAge-related sex differences in the outcomes of patients with hypertrophic cardiomyopathy.<h4>Background</h4>We aimed to clarify the sex differences in various cardiovascular and non-cardiovascular outcomes, and to investigate whether sex differences in outcomes are affected by age in hypertrophic cardiomyopathy (HCM).<h4>Methods</h4>A cohort of 835 patients with HCM initially evaluated during 2007-2019 were followed for a median of 6.4 years. Study outcomes were all-cause death, cardiovascular and non-cardiovascular death, sudden cardiac death (SCD)/SCD equivalent events, heart failure (HF) events, and the composite cardiovascular outcome including cardiovascular death, SCD/SCD equivalent events, admission for HF, and heart transplantation.<h4>Results</h4>Women were 5 years older (women 59.9±13.5 vs. men 54.9±11.4 years), had worse dyspnea, and greater left ventricular (LV) di2022-01-01T00:00:00Z20222025-04-04T08:58:29.975Z2025-04-04T08:58:29.975ZS-EPMC88803923521365310.1371/journal.pone.0264580