{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mduma E"],"funding":["World Health Organization","NIAID NIH HHS","Special Programme for Research and Training in Tropical Diseases","National Institutes of Health","Wellcome Trust"],"pagination":["e0264322"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8880396"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(2)"],"pubmed_abstract":["<h4>Background</h4>Serious invasive infections in newborns are a major cause of death. Lack of data on etiological causes hampers progress towards reduction of mortality. This study aimed to identify pathogens responsible for such infections in young infants in sub-Saharan Africa and to describe their antibiotics resistance profile.<h4>Methods</h4>Between September 2016 and April 2018 we implemented an observational study in two rural sites in Burkina Faso and Tanzania enrolling young infants aged 0-59 days old with serious invasive infection. Blood samples underwent blood culture and molecular biology.<h4>Results</h4>In total 634 infants with clinical diagnosis of serious invasive infection were enrolled and 4.2% of the infants had a positive blood culture. The most frequent pathogens ide"],"journal":["PloS one"],"pubmed_title":["Etiology of severe invasive infections in young infants in rural settings in sub-Saharan Africa."],"pmcid":["PMC8880396"],"funding_grant_id":["001","B40235","B40234","K24 AI102972"],"pubmed_authors":["Walongo T","Lompo P","Liu J","Guillerm M","Guga G","Mdoe P","Singlovic J","Halleux CM","Gomes MF","Kimathi C","Petzold M","Houpt ER","Museveni J","Gratz J","Moshiro R","Kabore B","Gidabayda J","Halidou T","Mduma E"],"additional_accession":[]},"is_claimable":false,"name":"Etiology of severe invasive infections in young infants in rural settings in sub-Saharan Africa.","description":"<h4>Background</h4>Serious invasive infections in newborns are a major cause of death. Lack of data on etiological causes hampers progress towards reduction of mortality. This study aimed to identify pathogens responsible for such infections in young infants in sub-Saharan Africa and to describe their antibiotics resistance profile.<h4>Methods</h4>Between September 2016 and April 2018 we implemented an observational study in two rural sites in Burkina Faso and Tanzania enrolling young infants aged 0-59 days old with serious invasive infection. Blood samples underwent blood culture and molecular biology.<h4>Results</h4>In total 634 infants with clinical diagnosis of serious invasive infection were enrolled and 4.2% of the infants had a positive blood culture. The most frequent pathogens ide","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T14:58:55.038Z","creation":"2025-04-04T14:58:55.038Z"},"accession":"S-EPMC8880396","cross_references":{"pubmed":["35213629"],"doi":["10.1371/journal.pone.0264322"]}}