{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(2)"],"submitter":["Ramdhan P"],"pubmed_abstract":["Methyltransferase enzymes have been associated with different processes within cells and viruses. Specifically, within viruses, methyltransferases are used to form the 5'cap-0 structure for optimal evasion of the host innate immune system. In this paper, we seek to discuss the various methyltransferases that exist within single-stranded RNA (ssRNA) viruses along with their respective inhibitors. Additionally, the importance of motifs such as the KDKE tetrad and glycine-rich motif in the catalytic activity of methyltransferases is discussed."],"journal":["Viruses"],"pagination":["379"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8880702"],"repository":["biostudies-literature"],"pubmed_title":["Targeting Viral Methyltransferases: An Approach to Antiviral Treatment for ssRNA Viruses."],"pmcid":["PMC8880702"],"pubmed_authors":["Li C","Ramdhan P"],"additional_accession":[]},"is_claimable":false,"name":"Targeting Viral Methyltransferases: An Approach to Antiviral Treatment for ssRNA Viruses.","description":"Methyltransferase enzymes have been associated with different processes within cells and viruses. Specifically, within viruses, methyltransferases are used to form the 5'cap-0 structure for optimal evasion of the host innate immune system. In this paper, we seek to discuss the various methyltransferases that exist within single-stranded RNA (ssRNA) viruses along with their respective inhibitors. Additionally, the importance of motifs such as the KDKE tetrad and glycine-rich motif in the catalytic activity of methyltransferases is discussed.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-04T07:55:03.478Z","creation":"2025-04-04T07:55:03.478Z"},"accession":"S-EPMC8880702","cross_references":{"pubmed":["35215972"],"doi":["10.3390/v14020379"]}}