biostudies-literatureUnknown14(2)Ramdhan PMethyltransferase enzymes have been associated with different processes within cells and viruses. Specifically, within viruses, methyltransferases are used to form the 5'cap-0 structure for optimal evasion of the host innate immune system. In this paper, we seek to discuss the various methyltransferases that exist within single-stranded RNA (ssRNA) viruses along with their respective inhibitors. Additionally, the importance of motifs such as the KDKE tetrad and glycine-rich motif in the catalytic activity of methyltransferases is discussed.Viruses379https://www.ebi.ac.uk/biostudies/studies/S-EPMC8880702biostudies-literatureTargeting Viral Methyltransferases: An Approach to Antiviral Treatment for ssRNA Viruses.PMC8880702Li CRamdhan PfalseTargeting Viral Methyltransferases: An Approach to Antiviral Treatment for ssRNA Viruses.Methyltransferase enzymes have been associated with different processes within cells and viruses. Specifically, within viruses, methyltransferases are used to form the 5'cap-0 structure for optimal evasion of the host innate immune system. In this paper, we seek to discuss the various methyltransferases that exist within single-stranded RNA (ssRNA) viruses along with their respective inhibitors. Additionally, the importance of motifs such as the KDKE tetrad and glycine-rich motif in the catalytic activity of methyltransferases is discussed.2022-01-01T00:00:00Z2022 Feb2025-04-04T07:55:03.478Z2025-04-04T07:55:03.478ZS-EPMC88807023521597210.3390/v14020379