{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["La Sala L"],"pubmed_abstract":["A successful vaccination would represent the most efficient means to control the pandemic of Coronavirus Disease-19 (COVID-19) that led to millions of deaths worldwide. Novel mRNA-based vaccines confer protective immunity against SARS-CoV-2, but whether immunity is immediately effective and how long it will remain in recipients are uncertain. We sought to assess the effectiveness of a two-dose regimen since the boosts are often delayed concerning the recommended intervals.<h4>Methods</h4>A longitudinal cohort of healthcare workers (HCW, <i>N</i> = 46; 30.4% men; 69.6% women; mean age 36.05 ± 2.2 years) with no SARS-CoV-2 infection as documented by negative polymerase chain reaction was immunophenotyped in PBMC once a week for 4 weeks from the prime immunization (Pfizer mRNA BNT162b2) and h"],"journal":["Frontiers in immunology"],"pagination":["798813"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8882867"],"repository":["biostudies-literature"],"pubmed_title":["SARS-CoV-2 Immunization Orchestrates the Amplification of IFNγ-Producing T Cell and NK Cell Persistence."],"pmcid":["PMC8882867"],"pubmed_authors":["Sommese C","Trabucchi E","Meregalli P","Allevi R","La Sala L","Palano MT","Longhi E","Gandini S","Gallazzi M","Senesi P","Luzi L","Bruno A"],"additional_accession":[]},"is_claimable":false,"name":"SARS-CoV-2 Immunization Orchestrates the Amplification of IFNγ-Producing T Cell and NK Cell Persistence.","description":"A successful vaccination would represent the most efficient means to control the pandemic of Coronavirus Disease-19 (COVID-19) that led to millions of deaths worldwide. Novel mRNA-based vaccines confer protective immunity against SARS-CoV-2, but whether immunity is immediately effective and how long it will remain in recipients are uncertain. We sought to assess the effectiveness of a two-dose regimen since the boosts are often delayed concerning the recommended intervals.<h4>Methods</h4>A longitudinal cohort of healthcare workers (HCW, <i>N</i> = 46; 30.4% men; 69.6% women; mean age 36.05 ± 2.2 years) with no SARS-CoV-2 infection as documented by negative polymerase chain reaction was immunophenotyped in PBMC once a week for 4 weeks from the prime immunization (Pfizer mRNA BNT162b2) and h","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T08:41:19.001Z","creation":"2025-04-04T08:41:19.001Z"},"accession":"S-EPMC8882867","cross_references":{"pubmed":["35237261"],"doi":["10.3389/fimmu.2022.798813"]}}