{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Scieszka D"],"funding":["The National Institute of Environmental Health Sciences","NIA NIH HHS","NIEHS NIH HHS","NIMHD NIH HHS","NIGMS NIH HHS"],"pagination":["149-162"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8883349"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["186(1)"],"pubmed_abstract":["Utilizing a mobile laboratory located >300 km away from wildfire smoke (WFS) sources, this study examined the systemic immune response profile, with a focus on neuroinflammatory and neurometabolomic consequences, resulting from inhalation exposure to naturally occurring wildfires in California, Arizona, and Washington in 2020. After a 20-day (4 h/day) exposure period in a mobile laboratory stationed in New Mexico, WFS-derived particulate matter (WFPM) inhalation resulted in significant neuroinflammation while immune activity in the peripheral (lung, bone marrow) appeared to be resolved in C57BL/6 mice. Importantly, WFPM exposure increased cerebrovascular endothelial cell activation and expression of adhesion molecules (VCAM-1 and ICAM-1) in addition to increased glial activation and periph"],"journal":["Toxicological sciences : an official journal of the Society of Toxicology"],"pubmed_title":["Neuroinflammatory and Neurometabolomic Consequences From Inhaled Wildfire Smoke-Derived Particulate Matter in the Western United States."],"pmcid":["PMC8883349"],"funding_grant_id":["R01 AG070776","P50 MD015706","R01 ES026673","P42 ES025589","P20 GM130422","R01 ES014639"],"pubmed_authors":["Canal CG","Hunter R","Begay J","Lin Y","Wagner J","Morishita M","Mostovenko E","Scieszka D","Klaver Z","Campen MJ","Gu H","Bolt A","Bleske B","Ottens AK","McVeigh C","Harkema JR","Herbert G","Noor S","Bitsui M","Lucas S","Galewsky J"],"additional_accession":[]},"is_claimable":false,"name":"Neuroinflammatory and Neurometabolomic Consequences From Inhaled Wildfire Smoke-Derived Particulate Matter in the Western United States.","description":"Utilizing a mobile laboratory located >300 km away from wildfire smoke (WFS) sources, this study examined the systemic immune response profile, with a focus on neuroinflammatory and neurometabolomic consequences, resulting from inhalation exposure to naturally occurring wildfires in California, Arizona, and Washington in 2020. After a 20-day (4 h/day) exposure period in a mobile laboratory stationed in New Mexico, WFS-derived particulate matter (WFPM) inhalation resulted in significant neuroinflammation while immune activity in the peripheral (lung, bone marrow) appeared to be resolved in C57BL/6 mice. Importantly, WFPM exposure increased cerebrovascular endothelial cell activation and expression of adhesion molecules (VCAM-1 and ICAM-1) in addition to increased glial activation and periph","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2026-05-05T18:11:15.36Z","creation":"2025-04-06T13:59:09.897Z"},"accession":"S-EPMC8883349","cross_references":{"pubmed":["34865172"],"doi":["10.1093/toxsci/kfab147"]}}