biostudies-literatureScieszka DThe National Institute of Environmental Health SciencesNIA NIH HHSNIEHS NIH HHSNIMHD NIH HHSNIGMS NIH HHS149-162https://www.ebi.ac.uk/biostudies/studies/S-EPMC8883349biostudies-literatureUnknown186(1)Utilizing a mobile laboratory located >300 km away from wildfire smoke (WFS) sources, this study examined the systemic immune response profile, with a focus on neuroinflammatory and neurometabolomic consequences, resulting from inhalation exposure to naturally occurring wildfires in California, Arizona, and Washington in 2020. After a 20-day (4 h/day) exposure period in a mobile laboratory stationed in New Mexico, WFS-derived particulate matter (WFPM) inhalation resulted in significant neuroinflammation while immune activity in the peripheral (lung, bone marrow) appeared to be resolved in C57BL/6 mice. Importantly, WFPM exposure increased cerebrovascular endothelial cell activation and expression of adhesion molecules (VCAM-1 and ICAM-1) in addition to increased glial activation and periphToxicological sciences : an official journal of the Society of ToxicologyNeuroinflammatory and Neurometabolomic Consequences From Inhaled Wildfire Smoke-Derived Particulate Matter in the Western United States.PMC8883349R01 AG070776P50 MD015706R01 ES026673P42 ES025589P20 GM130422R01 ES014639Canal CGHunter RBegay JLin YWagner JMorishita MMostovenko EScieszka DKlaver ZCampen MJGu HBolt ABleske BOttens AKMcVeigh CHarkema JRHerbert GNoor SBitsui MLucas SGalewsky JfalseNeuroinflammatory and Neurometabolomic Consequences From Inhaled Wildfire Smoke-Derived Particulate Matter in the Western United States.Utilizing a mobile laboratory located >300 km away from wildfire smoke (WFS) sources, this study examined the systemic immune response profile, with a focus on neuroinflammatory and neurometabolomic consequences, resulting from inhalation exposure to naturally occurring wildfires in California, Arizona, and Washington in 2020. After a 20-day (4 h/day) exposure period in a mobile laboratory stationed in New Mexico, WFS-derived particulate matter (WFPM) inhalation resulted in significant neuroinflammation while immune activity in the peripheral (lung, bone marrow) appeared to be resolved in C57BL/6 mice. Importantly, WFPM exposure increased cerebrovascular endothelial cell activation and expression of adhesion molecules (VCAM-1 and ICAM-1) in addition to increased glial activation and periph2022-01-01T00:00:00Z2022 Feb2026-05-05T18:11:15.36Z2025-04-06T13:59:09.897ZS-EPMC88833493486517210.1093/toxsci/kfab147