{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gu Y"],"funding":["Medical Field of Zhenjiang “Jin Shan Ying Cai” Project","Zhenjiang Clinical Research Center of Hematology","Scientific Research Foundation of Affiliated People&apos;s Hospital of Jiangsu University for PhD","National Natural Science foundation of China","Social Development Foundation of Zhenjiang"],"pagination":["38"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8886923"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["<h4>Background</h4>Recently, an increasing number of studies have reported that sperm-associated antigen (SPAG) proteins play crucial roles in solid tumorigenesis, and may serve as potentially helpful biomarkers for cancer diagnosis and prognosis. However, very few studies systematically investigated the expression of SPAG family members and their clinical significance in acute myeloid leukemia (AML).<h4>Methods</h4>The expression of SPAGs and their prognostic significance in AML were determined by a systematic analysis on data gathered from public databases, and the results were validated in clinical samples.<h4>Results</h4>Using public data, we identified only increased SPAG1 expression negatively associated with survival in AML by Cox regression (P < 0.001) and Kaplan-Meier analysis (P "],"journal":["BMC medical genomics"],"pubmed_title":["Comprehensive analysis of SPAG1 expression as a prognostic and predictive biomarker in acute myeloid leukemia by integrative bioinformatics and clinical validation."],"pmcid":["PMC8886923"],"funding_grant_id":["81900166","SH2020055","SS2018009","KFB202002"],"pubmed_authors":["Gu Y","Chu MQ","Yuan Q","Lin J","Zhou JD","Xu ZJ","Zhang TJ"],"additional_accession":[]},"is_claimable":false,"name":"Comprehensive analysis of SPAG1 expression as a prognostic and predictive biomarker in acute myeloid leukemia by integrative bioinformatics and clinical validation.","description":"<h4>Background</h4>Recently, an increasing number of studies have reported that sperm-associated antigen (SPAG) proteins play crucial roles in solid tumorigenesis, and may serve as potentially helpful biomarkers for cancer diagnosis and prognosis. However, very few studies systematically investigated the expression of SPAG family members and their clinical significance in acute myeloid leukemia (AML).<h4>Methods</h4>The expression of SPAGs and their prognostic significance in AML were determined by a systematic analysis on data gathered from public databases, and the results were validated in clinical samples.<h4>Results</h4>Using public data, we identified only increased SPAG1 expression negatively associated with survival in AML by Cox regression (P < 0.001) and Kaplan-Meier analysis (P ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2026-05-30T16:50:40.466Z","creation":"2025-02-19T05:04:57.011Z"},"accession":"S-EPMC8886923","cross_references":{"pubmed":["35227274"],"doi":["10.1186/s12920-022-01193-0"]}}