{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shen Z"],"funding":["Shanghai Science and Technology Committee","Shanghai Municipal Education Commission","Chinese Academy of Medical Sciences","NSFC","Shanghai Shen Kang Hospital Development Center","National Science and Technology Major Project of China"],"pagination":["2157-2171"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8887475"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["50(4)"],"pubmed_abstract":["Chronic infection with hepatitis B virus (HBV) is associated with liver cirrhosis and hepatocellular carcinoma. Upon infection of hepatocytes, HBV covalently closed circular DNA (cccDNA) exists as histone-bound mini-chromosome, subjected to transcriptional regulation similar to chromosomal DNA. Here we identify high mobility group AT-hook 1 (HMGA1) protein as a positive regulator of HBV transcription that binds to a conserved ATTGG site within enhancer II/core promoter (EII/Cp) and recruits transcription factors FOXO3α and PGC1α. HMGA1-mediated upregulation of EII/Cp results in enhanced viral gene expression and genome replication. Notably, expression of endogenous HMGA1 was also demonstrated to be upregulated by HBV, which involves HBV X protein (HBx) interacting with SP1 transcription fa"],"journal":["Nucleic acids research"],"pubmed_title":["High mobility group AT-hook 1 (HMGA1) is an important positive regulator of hepatitis B virus (HBV) that is reciprocally upregulated by HBV X protein."],"pmcid":["PMC8887475"],"funding_grant_id":["2017ZX10202202","2018ZX10301208","2018PT31044","201701070007E00057","82172255","81971931","20QA1401800","81971921","SHDC12019116","32170150","3157010371"],"pubmed_authors":["Wu J","Liu J","Shen Z","Xie Y","Chen J","He J","Guo Y","Zhang J","Deng Q","Gao Z","Zhang S"],"additional_accession":[]},"is_claimable":false,"name":"High mobility group AT-hook 1 (HMGA1) is an important positive regulator of hepatitis B virus (HBV) that is reciprocally upregulated by HBV X protein.","description":"Chronic infection with hepatitis B virus (HBV) is associated with liver cirrhosis and hepatocellular carcinoma. Upon infection of hepatocytes, HBV covalently closed circular DNA (cccDNA) exists as histone-bound mini-chromosome, subjected to transcriptional regulation similar to chromosomal DNA. Here we identify high mobility group AT-hook 1 (HMGA1) protein as a positive regulator of HBV transcription that binds to a conserved ATTGG site within enhancer II/core promoter (EII/Cp) and recruits transcription factors FOXO3α and PGC1α. HMGA1-mediated upregulation of EII/Cp results in enhanced viral gene expression and genome replication. Notably, expression of endogenous HMGA1 was also demonstrated to be upregulated by HBV, which involves HBV X protein (HBx) interacting with SP1 transcription fa","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2026-05-31T02:06:49.535Z","creation":"2025-04-04T23:03:09.532Z"},"accession":"S-EPMC8887475","cross_references":{"pubmed":["35137191"],"doi":["10.1093/nar/gkac070"]}}