{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Alsous JI"],"funding":["Javna Agencija za Raziskovalno Dejavnost RS","NIGMS NIH HHS","U.S. Department of Health &amp; Human Services | National Institutes of Health"],"pagination":["1391-1395"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8887698"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(12)"],"pubmed_abstract":["Clonal dominance arises when the descendants (clones) of one or a few founder cells contribute disproportionally to the final structure during collective growth [1-8]. In contexts such as bacterial growth, tumorigenesis, and stem cell reprogramming [2-4], this phenomenon is often attributed to pre-existing propensities for dominance, while in stem cell homeostasis, neutral drift dynamics are invoked [5,6]. The mechanistic origin of clonal dominance during development, where it is increasingly documented [1,6-8], is less understood. Here, we investigate this phenomenon in the <i>Drosophila melanogaster</i> follicle epithelium, a system in which the joint growth dynamics of cell lineage trees can be reconstructed. We demonstrate that clonal dominance can emerge spontaneously, in the absence "],"journal":["Nature physics"],"pubmed_title":["Clonal dominance in excitable cell networks."],"pmcid":["PMC8887698"],"funding_grant_id":["NIH R01GM134204-02","R01 GM134204","P1-0055"],"pubmed_authors":["Alsous JI","Shvartsman SY","Rozman J","Kosmrlj A","Marmion RA"],"additional_accession":[]},"is_claimable":false,"name":"Clonal dominance in excitable cell networks.","description":"Clonal dominance arises when the descendants (clones) of one or a few founder cells contribute disproportionally to the final structure during collective growth [1-8]. In contexts such as bacterial growth, tumorigenesis, and stem cell reprogramming [2-4], this phenomenon is often attributed to pre-existing propensities for dominance, while in stem cell homeostasis, neutral drift dynamics are invoked [5,6]. The mechanistic origin of clonal dominance during development, where it is increasingly documented [1,6-8], is less understood. Here, we investigate this phenomenon in the <i>Drosophila melanogaster</i> follicle epithelium, a system in which the joint growth dynamics of cell lineage trees can be reconstructed. We demonstrate that clonal dominance can emerge spontaneously, in the absence ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-25T22:29:12.12Z","creation":"2025-04-06T09:03:51.958Z"},"accession":"S-EPMC8887698","cross_references":{"pubmed":["35242199"],"doi":["10.1038/s41567-021-01383-0"]}}