biostudies-literatureMerrick CMNational Institutes of Healthe69977https://www.ebi.ac.uk/biostudies/studies/S-EPMC8887902biostudies-literatureUnknown11Neurophysiological studies in humans and nonhuman primates have revealed movement representations in both the contralateral and ipsilateral hemispheres. Inspired by clinical observations, we ask if this bilateral representation differs for the left and right hemispheres. Electrocorticography was recorded in human participants during an instructed-delay reaching task, with movements produced with either the contralateral or ipsilateral arm. Using a cross-validated kinematic encoding model, we found stronger bilateral encoding in the left hemisphere, an effect that was present during preparation and was amplified during execution. Consistent with this asymmetry, we also observed better across-arm generalization in the left hemisphere, indicating similar neural representations for right and leLifeLeft hemisphere dominance for bilateral kinematic encoding in the human brain.PMC8887902NS097480Breska AMerrick CMThomas Knight RChang EFLaxer KDLin JWeber PBIvry RBCarmena JDixon TCKing-Stephens DfalseLeft hemisphere dominance for bilateral kinematic encoding in the human brain.Neurophysiological studies in humans and nonhuman primates have revealed movement representations in both the contralateral and ipsilateral hemispheres. Inspired by clinical observations, we ask if this bilateral representation differs for the left and right hemispheres. Electrocorticography was recorded in human participants during an instructed-delay reaching task, with movements produced with either the contralateral or ipsilateral arm. Using a cross-validated kinematic encoding model, we found stronger bilateral encoding in the left hemisphere, an effect that was present during preparation and was amplified during execution. Consistent with this asymmetry, we also observed better across-arm generalization in the left hemisphere, indicating similar neural representations for right and l2022-01-01T00:00:00Z2022 Mar2025-04-04T08:41:04.747Z2025-04-04T08:41:04.747ZS-EPMC88879023522737410.7554/eLife.69977