biostudies-literatureHuang YNatural Science Foundation of Zhejiang ProvinceNational Natural Science Foundation of ChinaNational Key Research and Development Program of China818888https://www.ebi.ac.uk/biostudies/studies/S-EPMC8888916biostudies-literatureUnknown13Female fertility declines with age, and this natural variation culminates in reproductive senescence. Human follicular fluids are rich in low-molecular weight metabolites which are responsible for the maturation of oocytes. The metabolomic approaches are powerful tools to study biochemical markers of oocyte quality in the follicular fluids. It is necessary to identify and quantify the reliable metabolites in follicular fluids reflecting oocyte developmental potential. The goal of this study is to conduct a metabolomic analysis of the follicular fluids in women of different ages and study the metabolomic profile of the follicular fluids in relationship with oocyte quality in assisted reproductive technology (ART) treatment. A total of 30 women seeking for ART treatment at the Women's HospitFrontiers in endocrinologyAge-Dependent Metabolomic Profile of the Follicular Fluids From Women Undergoing Assisted Reproductive Technology Treatment.PMC8888916No. LZ18H040001, LQ21H040004No. 81974224No. 2018YFC1005003, 2021YFC2700601, 2021YFC2700402Zhang FLiu JZhang DChen KHu YChen LTu MYe YZhang RLiu YQian YXing LHuang YRuan YCYing YMa JChen YWu YfalseAge-Dependent Metabolomic Profile of the Follicular Fluids From Women Undergoing Assisted Reproductive Technology Treatment.Female fertility declines with age, and this natural variation culminates in reproductive senescence. Human follicular fluids are rich in low-molecular weight metabolites which are responsible for the maturation of oocytes. The metabolomic approaches are powerful tools to study biochemical markers of oocyte quality in the follicular fluids. It is necessary to identify and quantify the reliable metabolites in follicular fluids reflecting oocyte developmental potential. The goal of this study is to conduct a metabolomic analysis of the follicular fluids in women of different ages and study the metabolomic profile of the follicular fluids in relationship with oocyte quality in assisted reproductive technology (ART) treatment. A total of 30 women seeking for ART treatment at the Women's Hospit2022-01-01T00:00:00Z20222025-04-18T16:35:09.162Z2025-04-07T03:52:07.696ZS-EPMC88889163525087410.3389/fendo.2022.818888