{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hagler DJ"],"funding":["NICHD NIH HHS","NIDA NIH HHS","NIMH NIH HHS"],"pagination":["101086"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8889098"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["54"],"pubmed_abstract":["Influential investigations of postmortem human brain tissue showed regional differences in tissue properties at early phases of development, such as between prefrontal and primary sensory cortical regions. Large-scale neuroimaging studies enable characterization of age-related trajectories with much denser sampling of cortical regions, assessment ages, and demographic variables than postmortem tissue analyses, but no single imaging measure perfectly captures what is measured with histology. Using publicly available data from the Pediatric Imaging, Neurocognition, and Genetics (PING) study, including 951 participants with ages ranging from 3 to 21 years, we characterized cortical regional variability in developmental trajectories of multimodal brain imaging measures. Multivariate analyses i"],"journal":["Developmental cognitive neuroscience"],"pubmed_title":["Do aggregate, multimodal structural neuroimaging measures replicate regional developmental differences observed in highly cited cellular histological studies?"],"pmcid":["PMC8889098"],"funding_grant_id":["R01 MH118281","RC2 DA029475","U24 DA041123","R01 HD061414"],"pubmed_authors":["Akshoomoff N","Thompson WK","Brown TT","Hagler DJ","Pediatric Imaging, Neurocognition, and Genetics Study","Chen CH","Reuter C"],"additional_accession":[]},"is_claimable":false,"name":"Do aggregate, multimodal structural neuroimaging measures replicate regional developmental differences observed in highly cited cellular histological studies?","description":"Influential investigations of postmortem human brain tissue showed regional differences in tissue properties at early phases of development, such as between prefrontal and primary sensory cortical regions. Large-scale neuroimaging studies enable characterization of age-related trajectories with much denser sampling of cortical regions, assessment ages, and demographic variables than postmortem tissue analyses, but no single imaging measure perfectly captures what is measured with histology. Using publicly available data from the Pediatric Imaging, Neurocognition, and Genetics (PING) study, including 951 participants with ages ranging from 3 to 21 years, we characterized cortical regional variability in developmental trajectories of multimodal brain imaging measures. Multivariate analyses i","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-18T13:25:07.587Z","creation":"2025-04-06T23:06:51.715Z"},"accession":"S-EPMC8889098","cross_references":{"pubmed":["35220023"],"doi":["10.1016/j.dcn.2022.101086"]}}