biostudies-literatureUnknown22(1)Campanelli F<h4>Objective</h4>Early identification of sepsis is mandatory. However, clinical presentation is sometimes misleading given the lack of infection signs. The objective of the study was to evaluate the impact on the 28-day mortality of the so-called "vague" presentation of sepsis.<h4>Design</h4>Single centre retrospective observational study.<h4>Setting</h4>One teaching hospital Intensive Care Unit.<h4>Subjects</h4>All the patients who presented at the Emergency Department (ED) and were thereafter admitted to the Intensive Care Unit (ICU) with a final diagnosis of sepsis were included in this retrospective observational three-year study. They were classified as having exhibited either "vague" or explicit presentation at the ED according to previously suggested criteria. Baseline characteristBMC infectious diseases205https://www.ebi.ac.uk/biostudies/studies/S-EPMC8889780biostudies-literatureSeptic patients without obvious signs of infection at baseline are more likely to die in the ICU.PMC8889780Campanelli FAvondo ASoudry-Faure ARoudaut JBQuenot JPRay PCharles PEfalseSeptic patients without obvious signs of infection at baseline are more likely to die in the ICU.<h4>Objective</h4>Early identification of sepsis is mandatory. However, clinical presentation is sometimes misleading given the lack of infection signs. The objective of the study was to evaluate the impact on the 28-day mortality of the so-called "vague" presentation of sepsis.<h4>Design</h4>Single centre retrospective observational study.<h4>Setting</h4>One teaching hospital Intensive Care Unit.<h4>Subjects</h4>All the patients who presented at the Emergency Department (ED) and were thereafter admitted to the Intensive Care Unit (ICU) with a final diagnosis of sepsis were included in this retrospective observational three-year study. They were classified as having exhibited either "vague" or explicit presentation at the ED according to previously suggested criteria. Baseline characterist2022-01-01T00:00:00Z2022 Mar2025-04-26T18:27:07.56Z2024-11-20T12:39:42.425ZS-EPMC88897803523630810.1186/s12879-022-07210-y