{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["603(7899)"],"submitter":["Domizio JD"],"pubmed_abstract":["COVID-19, which is caused by infection with SARS-CoV-2, is characterized by lung pathology and extrapulmonary complications<sup>1,2</sup>. Type I interferons (IFNs) have an essential role in the pathogenesis of COVID-19 (refs <sup>3-5</sup>). Although rapid induction of type I IFNs limits virus propagation, a sustained increase in the levels of type I IFNs in the late phase of the infection is associated with aberrant inflammation and poor clinical outcome<sup>5-17</sup>. Here we show that the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, which controls immunity to cytosolic DNA, is a critical driver of aberrant type I IFN responses in COVID-19 (ref. <sup>18</sup>). Profiling COVID-19 skin manifestations, we uncover a STING-dependent type I IFN signature th"],"journal":["Nature"],"pagination":["145-151"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8891013"],"repository":["biostudies-literature"],"pubmed_title":["The cGAS-STING pathway drives type I IFN immunopathology in COVID-19."],"pmcid":["PMC8891013"],"pubmed_authors":["de Leval L","Nass T","Garnier CV","Thacker VV","Berezowska S","Domizio JD","Schaller M","Guenova E","Gulen MF","Sharma K","Ablasser A","Yatim A","Dubois A","Goepfert C","Saidoune F","Gilliet M","Conrad C"],"additional_accession":[]},"is_claimable":false,"name":"The cGAS-STING pathway drives type I IFN immunopathology in COVID-19.","description":"COVID-19, which is caused by infection with SARS-CoV-2, is characterized by lung pathology and extrapulmonary complications<sup>1,2</sup>. Type I interferons (IFNs) have an essential role in the pathogenesis of COVID-19 (refs <sup>3-5</sup>). Although rapid induction of type I IFNs limits virus propagation, a sustained increase in the levels of type I IFNs in the late phase of the infection is associated with aberrant inflammation and poor clinical outcome<sup>5-17</sup>. Here we show that the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, which controls immunity to cytosolic DNA, is a critical driver of aberrant type I IFN responses in COVID-19 (ref. <sup>18</sup>). Profiling COVID-19 skin manifestations, we uncover a STING-dependent type I IFN signature th","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T19:58:12.332Z","creation":"2025-04-04T19:58:12.332Z"},"accession":"S-EPMC8891013","cross_references":{"pubmed":["35045565"],"doi":["10.1038/s41586-022-04421-w"]}}