{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Chen L"],"pubmed_abstract":["<h4>Background</h4>Prostate cancer (PCa) is characterized by significant heterogeneity. Thus, novel prognostic indicators are required to improve prognosis and treatment.<h4>Methods</h4>Cysteine rich secretory protein 3 (CRISP3) and serine peptidase inhibitor Kazal type 1 (SPINK1) levels in expressed prostatic secretion (EPS)-urine collected during digital rectal examination of 496 patients histologically diagnosed with PCa were detected <i>via</i> enzyme-linked immunosorbent assay. A combined CRISP3 and SPINK1 prognostic grade (CSPG) was defined using cut-off values from receiver operating characteristic curves. Log-rank Kaplan-Meier survival curves investigated differences in prognosis between groups. Univariate and multivariate Cox analyses investigated the CSPG relationship with bioche"],"journal":["Frontiers in medicine"],"pagination":["832415"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8891445"],"repository":["biostudies-literature"],"pubmed_title":["A Combined CRISP3 and SPINK1 Prognostic Grade in EPS-Urine and Establishment of Models to Predict Prognosis of Patients With Prostate Cancer."],"pmcid":["PMC8891445"],"pubmed_authors":["Zhang E","Guan J","Chen Z","He J","Chen L","Yin B","Zhang M","Ye J","Liu W","Song Y"],"additional_accession":[]},"is_claimable":false,"name":"A Combined CRISP3 and SPINK1 Prognostic Grade in EPS-Urine and Establishment of Models to Predict Prognosis of Patients With Prostate Cancer.","description":"<h4>Background</h4>Prostate cancer (PCa) is characterized by significant heterogeneity. Thus, novel prognostic indicators are required to improve prognosis and treatment.<h4>Methods</h4>Cysteine rich secretory protein 3 (CRISP3) and serine peptidase inhibitor Kazal type 1 (SPINK1) levels in expressed prostatic secretion (EPS)-urine collected during digital rectal examination of 496 patients histologically diagnosed with PCa were detected <i>via</i> enzyme-linked immunosorbent assay. A combined CRISP3 and SPINK1 prognostic grade (CSPG) was defined using cut-off values from receiver operating characteristic curves. Log-rank Kaplan-Meier survival curves investigated differences in prognosis between groups. Univariate and multivariate Cox analyses investigated the CSPG relationship with bioche","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T09:00:41.635Z","creation":"2025-04-04T09:00:41.635Z"},"accession":"S-EPMC8891445","cross_references":{"pubmed":["35252264"],"doi":["10.3389/fmed.2022.832415"]}}