{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang R"],"funding":["NHLBI NIH HHS"],"pagination":["816551"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8891576"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["Mitophagy is an intracellular mechanism to maintain mitochondrial health by removing dysfunctional mitochondria. The E3 ligase Parkin ubiquitinates the membrane proteins on targeted mitochondria to initiate mitophagy, whereas USP30 antagonizes Parkin-dependent mitophagy by removing ubiquitin from Parkin substrates. The AKT/mTOR signaling is a master regulator of cell proliferation, differentiation, apoptosis, and autophagy. Although mounting evidence suggests that perturbations in the AKT/mTOR signaling pathway may contribute to mitophagy regulation, the specific mechanisms between Parkin/USP30 and AKT/mTOR signaling have not been elucidated. In this study, we employ a set of genetic reagents to investigate the role of Parkin and USP30 in regulating the AKT/mTOR signaling during mitophagy."],"journal":["Frontiers in pharmacology"],"pubmed_title":["The Mitochondrial Deubiquitinase USP30 Regulates AKT/mTOR Signaling."],"pmcid":["PMC8891576"],"funding_grant_id":["R01 HL160581"],"pubmed_authors":["Sun N","Luo H","Zhang R","Xin G","Ozgen S","Krigman J","Zhao Y"],"additional_accession":[]},"is_claimable":false,"name":"The Mitochondrial Deubiquitinase USP30 Regulates AKT/mTOR Signaling.","description":"Mitophagy is an intracellular mechanism to maintain mitochondrial health by removing dysfunctional mitochondria. The E3 ligase Parkin ubiquitinates the membrane proteins on targeted mitochondria to initiate mitophagy, whereas USP30 antagonizes Parkin-dependent mitophagy by removing ubiquitin from Parkin substrates. The AKT/mTOR signaling is a master regulator of cell proliferation, differentiation, apoptosis, and autophagy. Although mounting evidence suggests that perturbations in the AKT/mTOR signaling pathway may contribute to mitophagy regulation, the specific mechanisms between Parkin/USP30 and AKT/mTOR signaling have not been elucidated. In this study, we employ a set of genetic reagents to investigate the role of Parkin and USP30 in regulating the AKT/mTOR signaling during mitophagy.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T08:58:28.718Z","creation":"2025-04-04T08:58:28.718Z"},"accession":"S-EPMC8891576","cross_references":{"pubmed":["35250566"],"doi":["10.3389/fphar.2022.816551"]}}