{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fu Q"],"funding":["the Natural Science Foundation of Hubei Provincial Department of Education"],"pagination":["17448069221076460"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8891909"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18"],"pubmed_abstract":["Bone cancer pain (BCP) seriously affects the quality of life; however, due to its complex mechanism, the clinical treatment was unsatisfactory. Recent studies have showed several Rac-specific guanine nucleotide exchange factors (GEFs) that affect development and structure of neuronal processes play a vital role in the regulation of chronic pain. P-Rex2 is one of GEFs that regulate spine density, and the present study was performed to examine the effect of P-Rex2 on the development of BCP. Tumor cells implantation induced the mechanical hyperalgesia, which was accompanied by an increase in spinal protein P-Rex2, phosphorylated Rac1 (p-Rac1) and phosphorylated GluR1 (p-GluR1), and number of spines. Intrathecal injection a P-Rex2-targeting RNAi lentivirus relieved BCP and reduced the expressi"],"journal":["Molecular pain"],"pubmed_title":["P-Rex2 mediation of synaptic plasticity contributes to bone cancer pain."],"pmcid":["PMC8891909"],"funding_grant_id":["B2020109"],"pubmed_authors":["Wan S","Fu Q","Li X","Li Y","Su S","Huang X","Xu X","Wu Y"],"additional_accession":[]},"is_claimable":false,"name":"P-Rex2 mediation of synaptic plasticity contributes to bone cancer pain.","description":"Bone cancer pain (BCP) seriously affects the quality of life; however, due to its complex mechanism, the clinical treatment was unsatisfactory. Recent studies have showed several Rac-specific guanine nucleotide exchange factors (GEFs) that affect development and structure of neuronal processes play a vital role in the regulation of chronic pain. P-Rex2 is one of GEFs that regulate spine density, and the present study was performed to examine the effect of P-Rex2 on the development of BCP. Tumor cells implantation induced the mechanical hyperalgesia, which was accompanied by an increase in spinal protein P-Rex2, phosphorylated Rac1 (p-Rac1) and phosphorylated GluR1 (p-GluR1), and number of spines. Intrathecal injection a P-Rex2-targeting RNAi lentivirus relieved BCP and reduced the expressi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan-Dec","modification":"2025-04-04T07:50:49.043Z","creation":"2025-04-04T07:50:49.043Z"},"accession":"S-EPMC8891909","cross_references":{"pubmed":["35083941"],"doi":["10.1177/17448069221076460"]}}