biostudies-literatureWu YDirectorate for EngineeringNHLBI NIH HHSNIHNational Institute of General Medical SciencesNIGMS NIH HHSe1009400https://www.ebi.ac.uk/biostudies/studies/S-EPMC8893647biostudies-literatureUnknown18(2)In eukaryotes, the cell volume is observed to be strongly correlated with the nuclear volume. The slope of this correlation depends on the cell type, growth condition, and the physical environment of the cell. We develop a computational model of cell growth and proteome increase, incorporating the kinetics of amino acid import, protein/ribosome synthesis and degradation, and active transport of proteins between the cytoplasm and the nucleoplasm. We also include a simple model of ribosome biogenesis and assembly. Results show that the cell volume is tightly correlated with the nuclear volume, and the cytoplasm-nucleoplasm transport rates strongly influence the cell growth rate as well as the cell/nucleus volume ratio (C/N ratio). Ribosome assembly and the ratio of ribosomal proteins to matuPLoS computational biologyThe correlation between cell and nucleus size is explained by an eukaryotic cell growth model.PMC8893647DMR-1420570R35 GM136259P01 HL120839R01 GM134542R35GM136259P01HL120839R01GM134542Janmey PSun SXWu YPegoraro AFWeitz DAfalseThe correlation between cell and nucleus size is explained by an eukaryotic cell growth model.In eukaryotes, the cell volume is observed to be strongly correlated with the nuclear volume. The slope of this correlation depends on the cell type, growth condition, and the physical environment of the cell. We develop a computational model of cell growth and proteome increase, incorporating the kinetics of amino acid import, protein/ribosome synthesis and degradation, and active transport of proteins between the cytoplasm and the nucleoplasm. We also include a simple model of ribosome biogenesis and assembly. Results show that the cell volume is tightly correlated with the nuclear volume, and the cytoplasm-nucleoplasm transport rates strongly influence the cell growth rate as well as the cell/nucleus volume ratio (C/N ratio). Ribosome assembly and the ratio of ribosomal proteins to matu2022-01-01T00:00:00Z2022 Feb2025-04-19T13:21:18.778Z2025-04-19T13:21:18.778ZS-EPMC88936473518021510.1371/journal.pcbi.1009400