biostudies-literatureParagomi PNIDDK NIH HHSNCI NIH HHS85-91https://www.ebi.ac.uk/biostudies/studies/S-EPMC8894899biostudies-literatureUnknown22(1)<h4>Background/objectives</h4>The relationship between pre-existing diabetes mellitus (DM) and acute pancreatitis (AP) severity has not been established. We assessed the impact of pre-existing DM on AP severity in an international, prospectively ascertained registry.<h4>Methods</h4>APPRENTICE registry prospectively enrolled 1543 AP patients from 22 centers across 4 continents (8 US, 6 Europe, 5 Latin America, 3 India) between 2015 and 2018, and collected detailed clinical information. Pre-existing DM was defined a diagnosis of DM prior to AP admission. The primary outcome was AP severity defined by the Revised Atlanta Classification (RAC). Secondary outcomes were development of systemic inflammatory response syndrome (SIRS) or intensive care unit (ICU) admission.<h4>Results</h4>Pre-existinPancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]The relationship between pre-existing diabetes mellitus and the severity of acute pancreatitis: Report from a large international registry.PMC8894899U01 DK108306U01 DK127400U01 DK127388U01 DK127377T32 CA186873Stevens TLee PJZarnescu NParagomi PThakkar SOcampo CNawaz HFerreira Bogado MGutierrez SCWu BUTriantafyllou Kde-Madaria EConwell DLPothoulakis IGulla AHart PAKochhar RArchibugi LTalukdar RBarbu STToledo FGSSingh VKEasler JJCote GAPelaez-Luna MGonzalez JAHinton AYadav DJeong KGoenka MKPapachristou GIfalseThe relationship between pre-existing diabetes mellitus and the severity of acute pancreatitis: Report from a large international registry.<h4>Background/objectives</h4>The relationship between pre-existing diabetes mellitus (DM) and acute pancreatitis (AP) severity has not been established. We assessed the impact of pre-existing DM on AP severity in an international, prospectively ascertained registry.<h4>Methods</h4>APPRENTICE registry prospectively enrolled 1543 AP patients from 22 centers across 4 continents (8 US, 6 Europe, 5 Latin America, 3 India) between 2015 and 2018, and collected detailed clinical information. Pre-existing DM was defined a diagnosis of DM prior to AP admission. The primary outcome was AP severity defined by the Revised Atlanta Classification (RAC). Secondary outcomes were development of systemic inflammatory response syndrome (SIRS) or intensive care unit (ICU) admission.<h4>Results</h4>Pre-existin2022-01-01T00:00:00Z2022 Jan2025-04-22T10:09:36.255Z2025-04-05T23:29:51.876ZS-EPMC88948993465643110.1016/j.pan.2021.10.001