biostudies-literatureHsu SNational Center for Advancing Translational SciencesNational Center for Research ResourcesNCATS NIH HHSDiabetes Research CenterNIDDK NIH HHSNCRR NIH HHSNational Institute of Diabetes and Digestive and Kidney DiseasesNational Heart, Lung, and Blood InstituteNHLBI NIH HHSNational Institutes of HealthNIDDKUS Environmental Protection Agency914-924https://www.ebi.ac.uk/biostudies/studies/S-EPMC8895207biostudies-literatureUnknown115(3)<h4>Background</h4>Different 25-hydroxyvitamin D [25(OH)D] thresholds for treatment with vitamin D supplementation have been suggested and are derived almost exclusively from observational studies. Whether other characteristics, including race/ethnicity, BMI, and estimated glomerular filtration rate (eGFR), should also influence the threshold for treatment is unknown.<h4>Objectives</h4>The aim was to identify clinical and biomarker characteristics that modify the response to vitamin D supplementation.<h4>Methods</h4>A total of 666 older adults in the Multi-Ethnic Study of Atherosclerosis (MESA) were randomly assigned to 16 wk of oral vitamin D3 (2000 IU/d; n = 499) or placebo (n = 167). Primary outcomes were changes in serum parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D [1,25(OH)2DThe American journal of clinical nutritionClinical and biomarker modifiers of vitamin D treatment response: the Multi-Ethnic Study of Atherosclerosis.PMC8895207UL1-TR-001079UL1-TR-000040F32 DK128986UL1 TR001881N01-HC-95161N01-HC-95162N01-HC-95163UL1 RR0331761F32DK128986-01N01-HC-95164RD831697UL1-RR-025005N01-HC-95160R01-HL-071205N01-HC-95159R01DK09919975N92020D0000775N92020D0000175N92020D00002UL1-RR-033176P30 DK03581675N92020D0000575N92020D0000675N92020D0000375N92020D00004UL1-TR-001881R01 HL096875UL1-TR-001420R01DK0887622T32DK007467-36RD83830001N01-HC-95169R01HL096875N01-HC-95165N01-HC-95166R01-HL-071259N01-HC-95167N01-HC-95168R01-HL-071258R01-HL-071252DK063491P30 DK063491R01-HL-071051R01-HL-071251HHSN268201500003IR01-HL-071250Watson KEPsaty BMHoofnagle ANRotter JIRice KMWilliams KLiu KJBurke GLAllen NBHsu SLi XPrince DKSiscovick DMichos EDde Boer IHTracy RPKestenbaum BRMcClelland RLShea SJfalseClinical and biomarker modifiers of vitamin D treatment response: the Multi-Ethnic Study of Atherosclerosis.<h4>Background</h4>Different 25-hydroxyvitamin D [25(OH)D] thresholds for treatment with vitamin D supplementation have been suggested and are derived almost exclusively from observational studies. Whether other characteristics, including race/ethnicity, BMI, and estimated glomerular filtration rate (eGFR), should also influence the threshold for treatment is unknown.<h4>Objectives</h4>The aim was to identify clinical and biomarker characteristics that modify the response to vitamin D supplementation.<h4>Methods</h4>A total of 666 older adults in the Multi-Ethnic Study of Atherosclerosis (MESA) were randomly assigned to 16 wk of oral vitamin D3 (2000 IU/d; n = 499) or placebo (n = 167). Primary outcomes were changes in serum parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D [1,25(OH)2D2022-01-01T00:00:00Z2022 Mar2026-05-08T11:35:46.36Z2024-12-04T03:45:00.023ZS-EPMC88952073484954610.1093/ajcn/nqab390