{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Di Meglio A"],"funding":["Institut National du Cancer","Susan G. Komen","Conquer Cancer Foundation"],"pagination":["193"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8896231"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Background</h4>Elevated body mass index (BMI) represents a risk factor for cancer-related fatigue (CRF). Weight loss interventions are feasible and safe in cancer survivors, leading to improved cardio-metabolic and quality of life (QOL) outcomes and modulating inflammatory biomarkers. Randomized data are lacking showing that a lifestyle intervention aimed at weight loss, combining improved diet, exercise, and motivational counseling, reduces CRF. Motivating to Exercise and Diet, and Educating to healthy behaviors After breast cancer (MEDEA) is a multi-center, randomized controlled trial evaluating the impact of weight loss on CRF in overweight or obese survivors of breast cancer. Herein, we described the MEDEA methodology.<h4>Methods</h4>Patients (N = 220) with stage I-III breast cance"],"journal":["Trials"],"pubmed_title":["A phase III randomized trial of weight loss to reduce cancer-related fatigue among overweight and obese breast cancer patients: MEDEA Study design."],"pmcid":["PMC8896231"],"funding_grant_id":["RISP 2018-13684","Career Pathway Grant in Symptom Management","CCR17483507"],"pubmed_authors":["Raynard B","Pauporte I","Sirven A","Bouleuc C","Cottu PH","Michiels S","Lesur A","Barbier A","Tredan O","Segura-Djezzar C","Pistilli B","Joly F","Charles C","Vaz-Luis I","Ligibel JA","Ginsbourger T","Bonastre J","Martin E","Coquet B","Vanlemmens L","Mangin A","Di Meglio A","Jacob G","Crane TE"],"additional_accession":[]},"is_claimable":false,"name":"A phase III randomized trial of weight loss to reduce cancer-related fatigue among overweight and obese breast cancer patients: MEDEA Study design.","description":"<h4>Background</h4>Elevated body mass index (BMI) represents a risk factor for cancer-related fatigue (CRF). Weight loss interventions are feasible and safe in cancer survivors, leading to improved cardio-metabolic and quality of life (QOL) outcomes and modulating inflammatory biomarkers. Randomized data are lacking showing that a lifestyle intervention aimed at weight loss, combining improved diet, exercise, and motivational counseling, reduces CRF. Motivating to Exercise and Diet, and Educating to healthy behaviors After breast cancer (MEDEA) is a multi-center, randomized controlled trial evaluating the impact of weight loss on CRF in overweight or obese survivors of breast cancer. Herein, we described the MEDEA methodology.<h4>Methods</h4>Patients (N = 220) with stage I-III breast cance","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-18T12:09:42.958Z","creation":"2025-04-06T21:50:55.852Z"},"accession":"S-EPMC8896231","cross_references":{"pubmed":["35246219"],"doi":["10.1186/s13063-022-06090-6"]}}