biostudies-literatureDi Meglio AInstitut National du CancerSusan G. KomenConquer Cancer Foundation193https://www.ebi.ac.uk/biostudies/studies/S-EPMC8896231biostudies-literatureUnknown23(1)<h4>Background</h4>Elevated body mass index (BMI) represents a risk factor for cancer-related fatigue (CRF). Weight loss interventions are feasible and safe in cancer survivors, leading to improved cardio-metabolic and quality of life (QOL) outcomes and modulating inflammatory biomarkers. Randomized data are lacking showing that a lifestyle intervention aimed at weight loss, combining improved diet, exercise, and motivational counseling, reduces CRF. Motivating to Exercise and Diet, and Educating to healthy behaviors After breast cancer (MEDEA) is a multi-center, randomized controlled trial evaluating the impact of weight loss on CRF in overweight or obese survivors of breast cancer. Herein, we described the MEDEA methodology.<h4>Methods</h4>Patients (N = 220) with stage I-III breast canceTrialsA phase III randomized trial of weight loss to reduce cancer-related fatigue among overweight and obese breast cancer patients: MEDEA Study design.PMC8896231RISP 2018-13684Career Pathway Grant in Symptom ManagementCCR17483507Raynard BPauporte ISirven ABouleuc CCottu PHMichiels SLesur ABarbier ATredan OSegura-Djezzar CPistilli BJoly FCharles CVaz-Luis ILigibel JAGinsbourger TBonastre JMartin ECoquet BVanlemmens LMangin ADi Meglio AJacob GCrane TEfalseA phase III randomized trial of weight loss to reduce cancer-related fatigue among overweight and obese breast cancer patients: MEDEA Study design.<h4>Background</h4>Elevated body mass index (BMI) represents a risk factor for cancer-related fatigue (CRF). Weight loss interventions are feasible and safe in cancer survivors, leading to improved cardio-metabolic and quality of life (QOL) outcomes and modulating inflammatory biomarkers. Randomized data are lacking showing that a lifestyle intervention aimed at weight loss, combining improved diet, exercise, and motivational counseling, reduces CRF. Motivating to Exercise and Diet, and Educating to healthy behaviors After breast cancer (MEDEA) is a multi-center, randomized controlled trial evaluating the impact of weight loss on CRF in overweight or obese survivors of breast cancer. Herein, we described the MEDEA methodology.<h4>Methods</h4>Patients (N = 220) with stage I-III breast cance2022-01-01T00:00:00Z2022 Mar2025-04-18T12:09:42.958Z2025-04-06T21:50:55.852ZS-EPMC88962313524621910.1186/s13063-022-06090-6