{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bebell LM"],"funding":["National Institutes of Health"],"pagination":["100034"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8896824"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["1"],"pubmed_abstract":["Depression affects over 40% of people with HIV (PHIV) in low- and middle-income countries, and over half of PHIV report HIV-related internalized stigma. However, few longitudinal studies of PHIV have examined the relationship between HIV-related stigma and depression. Data were analyzed from the 2007-15 Uganda AIDS Rural Treatment Outcomes (UARTO) Study, a cohort of 454 antiretroviral therapy (ART)-naïve PHIV (68% women) starting ART. Our primary outcome was depression symptom severity over the first two years of ART, measured using a locally adapted version of the Hopkins Symptom Checklist; our primary exposure was the 6-item Internalized AIDS-Related Stigma Scale. Both scores were measured at enrollment and at quarterly follow-up visits. We fit linear generalized estimating equations (GE"],"journal":["SSM. Mental health"],"pubmed_title":["Internalized stigma, depressive symptoms, and the modifying role of antiretroviral therapy: A cohort study in rural Uganda."],"pmcid":["PMC8896824"],"funding_grant_id":["K23AI138856","R01MH113494","R01MH054907","K24AA015287","K23MH108440"],"pubmed_authors":["Bebell LM","Bwana MB","Siedner MJ","Boum Y","Haberer JE","Martin JN","Tsai AC","Musinguzi N","Kembabazi A","Muzoora C","O'Laughlin KN","Hunt PW","Bangsberg DR"],"additional_accession":[]},"is_claimable":false,"name":"Internalized stigma, depressive symptoms, and the modifying role of antiretroviral therapy: A cohort study in rural Uganda.","description":"Depression affects over 40% of people with HIV (PHIV) in low- and middle-income countries, and over half of PHIV report HIV-related internalized stigma. However, few longitudinal studies of PHIV have examined the relationship between HIV-related stigma and depression. Data were analyzed from the 2007-15 Uganda AIDS Rural Treatment Outcomes (UARTO) Study, a cohort of 454 antiretroviral therapy (ART)-naïve PHIV (68% women) starting ART. Our primary outcome was depression symptom severity over the first two years of ART, measured using a locally adapted version of the Hopkins Symptom Checklist; our primary exposure was the 6-item Internalized AIDS-Related Stigma Scale. Both scores were measured at enrollment and at quarterly follow-up visits. We fit linear generalized estimating equations (GE","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-05-18T12:33:03.62Z","creation":"2025-04-04T23:29:11.236Z"},"accession":"S-EPMC8896824","cross_references":{"pubmed":["35252904"],"doi":["10.1016/j.ssmmh.2021.100034"]}}